Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial[S]
Autor: | Genfu Tang, Xiangyi Kong, Min Zhao, Fan Fan Hou, Yanhong Liu, Yi Wang, Xianhui Qin, Xiping Xu, Fangfang Fan, Wen Wang, Binyan Wang, Yong Huo, Yupeng Wang, Yu Wang, Scott A. Venners, Ningling Sun, Wei Gao, Yan Zhang, Jianping Li, Shanqun Jiang |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Male Lymphocyte 030204 cardiovascular system & hematology Biochemistry total leukocyte Leukocyte Count 0302 clinical medicine Endocrinology Risk Factors Stroke education.field_of_study neutrophil Middle Aged Lipids Peripheral medicine.anatomical_structure Cholesterol Cardiovascular Diseases Hypertension lipids (amino acids peptides and proteins) epidemiology Female CSPPT medicine.medical_specialty China Population Cardiovascular risk factors QD415-436 lymphocyte Leukocyte Counts 03 medical and health sciences Internal medicine Primary prevention medicine Humans education Triglycerides Aged Dyslipidemias business.industry Cholesterol HDL Cell Biology Cholesterol LDL medicine.disease Surgery 030104 developmental biology business Patient-Oriented and Epidemiological Research Dyslipidemia |
Zdroj: | Journal of Lipid Research Journal of Lipid Research, Vol 58, Iss 1, Pp 256-266 (2017) |
ISSN: | 1539-7262 0022-2275 |
Popis: | The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. A total of 10,866 patients with hypertension were enrolled for a comprehensive assessment of cardiovascular risk factors using data from the China Stroke Primary Prevention Trial. Plasma lipid levels and total leukocyte, neutrophil, and lymphocyte counts were determined according to standard methods. Peripheral differential leukocyte counts were consistently and positively associated with serum total cholesterol (TC), LDL cholesterol (LDL-C), and TG levels (all P < 0.001 for trend), while inversely associated with HDL cholesterol levels (P < 0.05 for trend). In subsequent analyses where serum lipids were dichotomized (dyslipidemia/normolipidemia), we found that patients in the highest quartile of total leukocyte count (≥7.6 × 109 cells/l) had 1.64 times the risk of high TG [95% confidence interval (CI): 1.46, 1.85], 1.34 times the risk of high TC (95% CI: 1.20, 1.50), and 1.24 times the risk of high LDL-C (95% CI: 1.12, 1.39) compared with their counterparts in the lowest quartile of total leukocyte count. Similar patterns were also observed with neutrophils and lymphocytes. In summary, these findings indicate that elevated differential leukocyte counts are directly associated with serum lipid levels and increased odds of dyslipidemia. |
Databáze: | OpenAIRE |
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