Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial[S]

Autor: Genfu Tang, Xiangyi Kong, Min Zhao, Fan Fan Hou, Yanhong Liu, Yi Wang, Xianhui Qin, Xiping Xu, Fangfang Fan, Wen Wang, Binyan Wang, Yong Huo, Yupeng Wang, Yu Wang, Scott A. Venners, Ningling Sun, Wei Gao, Yan Zhang, Jianping Li, Shanqun Jiang
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Lymphocyte
030204 cardiovascular system & hematology
Biochemistry
total leukocyte
Leukocyte Count
0302 clinical medicine
Endocrinology
Risk Factors
Stroke
education.field_of_study
neutrophil
Middle Aged
Lipids
Peripheral
medicine.anatomical_structure
Cholesterol
Cardiovascular Diseases
Hypertension
lipids (amino acids
peptides
and proteins)
epidemiology
Female
CSPPT
medicine.medical_specialty
China
Population
Cardiovascular risk factors
QD415-436
lymphocyte
Leukocyte Counts
03 medical and health sciences
Internal medicine
Primary prevention
medicine
Humans
education
Triglycerides
Aged
Dyslipidemias
business.industry
Cholesterol
HDL
Cell Biology
Cholesterol
LDL
medicine.disease
Surgery
030104 developmental biology
business
Patient-Oriented and Epidemiological Research
Dyslipidemia
Zdroj: Journal of Lipid Research
Journal of Lipid Research, Vol 58, Iss 1, Pp 256-266 (2017)
ISSN: 1539-7262
0022-2275
Popis: The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. A total of 10,866 patients with hypertension were enrolled for a comprehensive assessment of cardiovascular risk factors using data from the China Stroke Primary Prevention Trial. Plasma lipid levels and total leukocyte, neutrophil, and lymphocyte counts were determined according to standard methods. Peripheral differential leukocyte counts were consistently and positively associated with serum total cholesterol (TC), LDL cholesterol (LDL-C), and TG levels (all P < 0.001 for trend), while inversely associated with HDL cholesterol levels (P < 0.05 for trend). In subsequent analyses where serum lipids were dichotomized (dyslipidemia/normolipidemia), we found that patients in the highest quartile of total leukocyte count (≥7.6 × 109 cells/l) had 1.64 times the risk of high TG [95% confidence interval (CI): 1.46, 1.85], 1.34 times the risk of high TC (95% CI: 1.20, 1.50), and 1.24 times the risk of high LDL-C (95% CI: 1.12, 1.39) compared with their counterparts in the lowest quartile of total leukocyte count. Similar patterns were also observed with neutrophils and lymphocytes. In summary, these findings indicate that elevated differential leukocyte counts are directly associated with serum lipid levels and increased odds of dyslipidemia.
Databáze: OpenAIRE
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