Associations with retinal nerve fiber layer measures in the EPIC-Norfolk Eye Study
| Autor: | Shabina Hayat, David F. Garway-Heath, Robert Luben, Anthony P Khawaja, Michelle P.Y. Chan, David C Broadway, Justin C Sherwin, Paul J. Foster, Kay-Tee Khaw |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Retinal Ganglion Cells Intraocular pressure medicine.medical_specialty Biometry Population Glaucoma Sex Factors Ophthalmology Confidence Intervals Prevalence Medicine Humans Prospective Studies Prospective cohort study education Generalized estimating equation Intraocular Pressure Aged Ultrasonography Aged 80 and over education.field_of_study business.industry Age Factors Articles Middle Aged medicine.disease eye diseases Confidence interval United Kingdom Axial Length Eye Female sense organs business Body mass index Tomography Optical Coherence Cohort study Follow-Up Studies |
| Zdroj: | Investigative ophthalmologyvisual science. 54(7) |
| ISSN: | 1552-5783 |
| Popis: | PURPOSE To describe GDxVCC retinal nerve fiber layer (RNFL) measures and associations in a predominantly white British population. METHODS The EPIC-Norfolk Eye Study is nested within a large multicenter cohort study, the European Prospective Investigation of Cancer. RNFL measurements were taken using the GDxVCC. Generalized estimating equation models were used to assess associations of RNFL measures with age, sex, body mass index (BMI), height, blood pressure, social class, education level, alcohol intake, smoking status, axial length, intraocular pressure, and lens status. Models were linearly adjusted for typical scan score to handle scans with atypical retardation. RESULTS There were complete data from 11,030 eyes of 6309 participants with mean age 68 years (48-90 years). Older age (-1.53 μm/decade [95% confidence interval {CI} -1.73, -1.33], P < 0.001), male sex (-0.44 μm [95% CI -0.04, -0.84], P = 0.031), shorter axial length (-0.15 μm/mm [95% CI -0.02, -0.28], P = 0.024), and pseudophakia (-0.49 μm [95% CI -0.94, -0.04], P = 0.033) were associated with thinner RNFL after adjustment for possible confounders. Higher BMI was associated with a thinner RNFL in men only (-0.30 μm/5 kg/m(2) [95% CI -0.58, -0.02], P = 0.039). CONCLUSIONS This analysis of associations with RNFL thickness in a largely healthy population may provide insight into the determinants of glaucoma, suggesting higher risk in those who are older, in men, and in men with a higher BMI. |
| Databáze: | OpenAIRE |
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