Comparing GnRH agonist long protocol and GnRH antagonist protocol in outcome the first cycle of ART
| Autor: | Homa Oskouian, Shahnaz Ahmadi, Robab Davar, Razieh Dehghani Firouzabadi |
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| Rok vydání: | 2009 |
| Předmět: |
Agonist
Infertility Adult endocrine system medicine.medical_specialty Pregnancy Rate medicine.drug_class medicine.medical_treatment Ovarian hyperstimulation syndrome Buserelin Andrology Gonadotropin-Releasing Hormone Follicle-stimulating hormone Ovulation Induction Pregnancy Internal medicine Medicine Humans Prospective Studies Assisted reproductive technology business.industry Antagonist Obstetrics and Gynecology General Medicine medicine.disease Embryo transfer Pregnancy rate Endocrinology Female Follicle Stimulating Hormone Human business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Archives of gynecology and obstetrics. 281(1) |
| ISSN: | 1432-0711 |
| Popis: | This prospective study evaluated the efficacy of gonadotropin-releasing hormone (GnRH) antagonist protocol in comparison with the GnRH agonist protocol in the first cycle of assisted reproductive technique (ART). We randomized 235 patients undergoing ART for the first time. The first group was stimulated with a standard long protocol and the second group stimulated with GnRH antagonis. There was no statistically significant difference in the age, infertility cause, basal FSH, BMI, the number of oocytes retrieved, number of M2 oocytes, embryo obtained and endometrial thickness between the two groups. But Serum estradiol, consumption of gonadotropins and ovarian hyperstimulation syndrome were significantly lower in the antagonist protocol. Cancellation rate of embryo transfer due to poor-quality embryo in the antagonist protocol was higher, but it was not significant. There was no significant difference in the clinical pregnancy and ongoing pregnancy between the two groups. GnRH-antagonist is an effective, safe, and well-tolerated alternative to agonist in the first cycle of ART. |
| Databáze: | OpenAIRE |
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