Utilizing Whole Slide Images for the Primary Evaluation and Peer Review of a GLP-Compliant Rodent Toxicology Study
| Autor: | Shane Ryan, Arthur Lewis, Dan Rudmann, Matt Jacobsen, James Baily, Alain Fraser |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
040301 veterinary sciences Computer science Rodentia 04 agricultural and veterinary sciences Cell Biology Toxicology 030226 pharmacology & pharmacy Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Workflow Artificial Intelligence Whole slide image medicine Image Processing Computer-Assisted Animals Medical physics Good laboratory practice Molecular Biology Software |
| Zdroj: | Toxicologic pathology. 49(6) |
| ISSN: | 1533-1601 |
| Popis: | The approach undertaken to deliver a Good Laboratory Practice (GLP) validation of whole slide images (WSIs) and the associated workflow for the digital primary evaluation and peer review of a GLP-compliant rodent inhalation toxicity study is described. The contract research organization (CRO) undertook validation of the slide scanner, scanner software, and associated database software. This provided a GLP validated environment within the database software for the primary histopathologic evaluation using WSI and viewed with the database software web viewer. The CRO also validated a cloud-based digital pathology platform that supported the upload and transfer of WSI and metadata to a cache within the sponsor's local area network. The sponsor undertook a separate GLP validation of the same cloud-based digital pathology platform to cover the download and review of the WSI. The establishment of a fit-for-purpose GLP-compliant workflow for WSI and successful deployment for the digital primary evaluation and peer review of a large GLP toxicology study enabled flexibility in accelerated global working and potential future reuse of digitized data for advanced artificial intelligence and machine learning image analysis. |
| Databáze: | OpenAIRE |
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