High-Frequency, but Reduced Absolute Numbers of Recent Thymic Migrants among Peripheral Blood T Lymphocytes in Diabetes-Prone BB Rats
| Autor: | Jaap Kampinga, Herman Groen, Flip A. Klatter, Paul Nieuwenhuis, Auk S. Wubbena, Nicolaas H.C. Brons |
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| Rok vydání: | 1995 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte medicine.medical_specialty medicine.drug_class T cell Immunology Population Thymus Gland Biology Monoclonal antibody Interleukin 21 Cell Movement T-Lymphocyte Subsets Internal medicine Diabetes mellitus medicine Animals Cytotoxic T cell Rats Inbred BB education ADP Ribose Transferases Protein Tyrosine Phosphatase Non-Receptor Type 1 education.field_of_study Membrane Glycoproteins Rats Inbred Strains Flow Cytometry medicine.disease Phenotype Rats Peripheral Diabetes Mellitus Type 1 Endocrinology medicine.anatomical_structure Leukocyte Common Antigens Thy-1 Antigens |
| Zdroj: | Cellular Immunology. 163:113-119 |
| ISSN: | 0008-8749 |
| Popis: | In rats, RT6 and CD45RC are expressed by mature peripheral T cells. The underrepresentation of T cells expressing these markers in the T lymphocytopenic BB rat might therefore be a reflection of a relatively immature T cell population. With the use of Thy-1 as a marker for recent thymic migrants, it was demonstrated that BB rats indeed have a phenotypically less mature T cell population than age-matched control rats. However, this could not account for the reduced percentages of RT6+ and CD45RC+ T cells, as these were also decreased among mature Thy-1- T cells of BB rats. Although relatively overrepresented, absolute numbers of Thy-1+ T cells were reduced in BB rats. Absolute numbers of mature Thy-1- T cells were also reduced in BB rats, but to a much larger degree than would proportionally be expected. Our findings taken together led us to conclude that both reduced thymic output and a defect in peripheral expansion are involved in the T lymphocytopenia of BB rats. |
| Databáze: | OpenAIRE |
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