Mechanically robust electrospun hydrogel scaffolds crosslinked via supramolecular interactions

Autor: Noortje A.M. Bax, Parinaz Goodarzy Fard, Björne B. Mollet, Patricia Y. W. Dankers, Sergio Spaans, Carlijn V. C. Bouten
Přispěvatelé: Soft Tissue Biomech. & Tissue Eng., Biomedical Engineering
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Polymers and Plastics
02 engineering and technology
mechanical properties
01 natural sciences
Gelatin
Polyethylene Glycols
chemistry.chemical_compound
Tissue engineering
Materials Chemistry
Myocytes
Cardiac
Fiber
Composite material
Cross-Linking Reagents/chemistry
chemistry.chemical_classification
Tissue Scaffolds
Hydrogels
Polymer
021001 nanoscience & nanotechnology
Electrospinning
Polyethylene Glycols/chemistry
Cross-Linking Reagents
Self-healing hydrogels
0210 nano-technology
Cardiac
Biotechnology
Gelatin/chemistry
Materials science
food.ingredient
Supramolecular chemistry
Bioengineering
macromolecular substances
010402 general chemistry
Cell Line
Biomaterials
Tissue Scaffolds/chemistry
food
hybrid hydrogels
Humans
Myocytes
Tissue Engineering
technology
industry
and agriculture
electrospun meshes
Epithelial Cells
Hydrogels/chemistry
0104 chemical sciences
chemistry
Chemical engineering
supramolecular biomaterials
Ethylene glycol
Zdroj: Macromolecular Bioscience, 17(9):1700053. Wiley-VCH Verlag
ISSN: 1616-5187
Popis: One of the major challenges in the processing of hydrogels based on poly(ethylene glycol) (PEG) is to create mechanically robust electrospun hydrogel scaffolds without chemical crosslinking postprocessing. In this study, this is achieved by the introduction of physical crosslinks in the form of supramolecular hydrogen bonding ureido-pyrimidinone (UPy) moieties, resulting in chain-extended UPy-PEG polymers (CE-UPy-PEG) that can be electrospun from organic solvent. The resultant fibrous meshes are swollen in contact with water and form mechanically stable, elastic hydrogels, while the fibrous morphology remains intact. Mixing up to 30 wt% gelatin with these CE-UPy-PEG polymers introduce bioactivity into these scaffolds, without affecting the mechanical properties. Manipulating the electrospinning parameters results in meshes with either small or large fiber diameters, i.e., 0.63 ± 0.36 and 2.14 ± 0.63 µm, respectively. In that order, these meshes provide support for renal epithelial monolayer formation or a niche for the culture of cardiac progenitor cells.
Databáze: OpenAIRE
Externí odkaz: