Ghrelin reductions following bariatric surgery were associated with decreased resting state activity in the hippocampus
| Autor: | Yang Hu, Kaichun Wu, Yongzhan Nie, Guanya Li, Jie Tian, Kai Yuan, Antao Chen, Jizheng Zhao, Nora D. Volkow, Gene-Jack Wang, Qingchuan Zhao, Peter Manza, Karen M. von Deneen, Jixn Liu, Qianqian Meng, Dardo Tomasi, Li Liu, Huaning Wang, Guangbin Cui, Qingchao Jin, Yi Zhang, Gang Ji |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism media_common.quotation_subject Appetite Bariatric Surgery Medicine (miscellaneous) Hippocampus 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Weight Loss medicine Humans 030212 general & internal medicine media_common Nutrition and Dietetics Resting state fMRI business.industry Leptin digestive oral and skin physiology Fasting Health Surveys Magnetic Resonance Imaging Ghrelin Obesity Morbid Surgery Dorsolateral prefrontal cortex Treatment Outcome medicine.anatomical_structure Posterior cingulate Female business Insula |
| Zdroj: | International Journal of Obesity. 43:842-851 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/s41366-018-0126-x |
| Popis: | Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric surgery to treat obesity, and involves removal of the gastric fundus where ghrelin is mainly produced. Ghrelin stimulates appetite and regulates food intake through its effect on the hypothalamus and hippocampus (HIPP). While ghrelin’s role on the hypothalamus has been explored, little is known about its role on HIPP. We tested the hypothesis that LSG-induced reductions in ghrelin levels would be associated with changes in HIPP activity. Brain activity was measured with amplitude of low-frequency fluctuations (ALFF) captured with resting-state functional magnetic resonance imaging (fMRI) in 30 obese participants, both before and after 1-month of LSG, and in 26 obese controls without surgery that were studied at baseline and 1-month later. A two-way analysis of variance (ANOVA) was performed to model the group and time effects on ALFF and resting-state functional connectivity. One-month post-LSG there were significant decreases in appetite, body mass index (BMI), fasting plasma ghrelin and leptin levels, anxiety, and ALFF in HIPP and ALFF increases in posterior cingulate cortex (PCC, PFWE |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink