Investigating the Physical Effects in Bacterial Therapies for Avascular Tumors
Autor: | Pietro Mascheroni, Michael Meyer-Hermann, Haralampos Hatzikirou |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Microbiology (medical)
Population Tumor spheroid lcsh:QR1-502 Microbiology lcsh:Microbiology 03 medical and health sciences Killing rate Immune system medicine cancer Tumor growth chemotaxis education 030304 developmental biology Original Research bacterial therapy 0303 health sciences education.field_of_study Low oxygen biology 030306 microbiology Chemistry Spheroid mathematical modeling Chemotaxis medicine.disease biology.organism_classification Cell biology space competition Cancer research Constant infusion Infiltration (medical) Bacteria |
Zdroj: | Frontiers in microbiology Switzerland Frontiers in Microbiology Frontiers in Microbiology, Vol 11 (2020) |
Popis: | Tumor-targeting bacteria elicit anticancer effects by infiltrating hypoxic regions, releasing toxic agents and inducing immune responses. Although current research has largely focused on the influence of chemical and immunological aspects on the mechanisms of bacterial therapy, the impact of physical effects is still elusive. Here, we propose a mathematical model for the anti-tumor activity of bacteria in avascular tumors that takes into account the relevant chemo-mechanical effects. We consider a time-dependent administration of bacteria and analyze the impact of bacterial chemotaxis and killing rate. We show that active bacterial migration towards tumor hypoxic regions provides optimal infiltration and that high killing rates combined with high chemotactic values provide the smallest tumor volumes at the end of the treatment. We highlight the emergence of steady states in which a small population of bacteria is able to constrain tumor growth. Finally, we show that bacteria treatment works best in the case of tumors with high cellular proliferation and low oxygen consumption. |
Databáze: | OpenAIRE |
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