Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity
| Autor: | Jean Claude Hannaert, Daniel Pipeleers, Miriam Cnop |
|---|---|
| Přispěvatelé: | Pathologic Biochemistry and Physiology |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Necrosis Hypoglycemic Agents -- pharmacology Endocrinology Diabetes and Metabolism Peroxisome proliferator-activated receptor Fatty Acids Nonesterified In Vitro Techniques Biology Biochemistry Chromans/pharmacology Hypoglycemic Agents/pharmacology Islets of Langerhans Troglitazone Fatty Acids Nonesterified/pharmacology Internal medicine Islets of Langerhans -- drug effects Thiazoles/pharmacology medicine Hypoglycemic Agents Animals Drug Interactions Chromans Rats Wistar Pharmacology chemistry.chemical_classification Islets of Langerhans -- physiology Fatty acid Islets of Langerhans/drug effects Fatty Acids Nonesterified -- pharmacology Thiazoles -- pharmacology Rats Thiazoles Endocrinology chemistry Lipotoxicity Apoptosis Toxicity Chromans -- pharmacology Thiazolidinediones Beta cell medicine.symptom Médecine clinique [biologie clinique] medicine.drug |
| Zdroj: | Biochemical Pharmacology, 63 |
| Popis: | Thiazolidinediones are a novel class of antidiabetic drugs that reduce insulin resistance through interaction with nuclear peroxisome proliferator-activated receptor (PPAR)gamma. One of these agents, troglitazone, was also proposed to protect beta cells against FFA-induced toxicity, but this effect has not yet been directly demonstrated. We recently reported in vitro conditions under which free fatty acids (FFA) cause beta cell death by necrosis or apoptosis. The present study investigates whether troglitazone (10 microM) interferes with this FFA-induced toxicity. Addition of this compound did not protect against oleate- or palmitate-induced toxicity. On the contrary, it increased palmitate-induced necrosis during the first two days of culture, and elevated (increase by 10-20%, P In Vitro Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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