Different β-cell secretory phenotype in non-obese compared to obese early type 2 diabetes

Autor:	Marina Cuchel, Carissa Fuller, Michael R. Rickels, Nora K. Rosenfeld, Lalitha Gudipaty
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Blood Glucose Male medicine.medical_specialty endocrine system endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Cell 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Article 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Diabetes mellitus Insulin-Secreting Cells Insulin Secretion Internal Medicine medicine Humans Obesity Proinsulin business.industry Insulin nutritional and metabolic diseases Long-term potentiation Middle Aged medicine.disease Prognosis medicine.anatomical_structure Phenotype Diabetes Mellitus Type 2 Case-Control Studies Female business Biomarkers Follow-Up Studies
Zdroj:	Diabetes Metab Res Rev
Popis:	BACKGROUND: Type 2 diabetes (T2D) is characterized by impaired tissue sensitivity to insulin action (ie, insulin resistance) and impaired β-cell insulin secretion. Because obesity contributes importantly to the development of insulin resistance, we sought to determine whether insulin secretory defects would predominate in non-obese compared to obese T2D. METHODS: We measured β-cell function and secretory capacity using the glucose-potentiated arginine test in T2D subjects early in the disease course classified as non-obese (BMI
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b4044f28207f810596a46b6b36610d https://europepmc.org/articles/PMC7864552/ Zobrazit plný text záznamu