Gonadotropin stimulates ovarian renin-angiotensin system in the rabbit
| Autor: | Masao Akiba, Akari Yoshinaga, M Karube, Shigetatsu Shiokawa, N Koyama, Yukio Nakamura, Takahisa Oda, Yasunori Yoshimura, Masao Jinno |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Ovulation
medicine.medical_specialty endocrine system Captopril Time Factors medicine.drug_class media_common.quotation_subject Ovary Biology In Vitro Techniques Chorionic Gonadotropin Human chorionic gonadotropin Renin-Angiotensin System Ovarian Follicle Internal medicine Renin–angiotensin system medicine Animals Ovarian follicle media_common Angiotensin II General Medicine Perfusion Kinetics medicine.anatomical_structure Endocrinology Oocytes Female Rabbits Gonadotropin hormones hormone substitutes and hormone antagonists medicine.drug Research Article |
| Popis: | The present study was undertaken to assess the role of ovarian renin-angiotensin system (RAS) in the preovulatory cascade induced by gonadotropin exposure. In the in vitro perfused rabbit ovaries, exposure to human chorionic gonadotropin (hCG) enhanced the secretion rate of angiotensin II (Ang II) within 1 h. The secretion rate reached maximal levels at 6 h and then declined thereafter. The intrafollicular Ang II content and renin-like activity were also significantly increased at 2 and 4 h after exposure to hCG, compared with control ovaries perfused with medium alone. The level of intrafollicular Ang II after hCG exposure significantly exceeded the concentration of Ang II in an equivalent volume of plasma. The addition of 1 microM captopril to the perfusate significantly inhibited the secretion rate of Ang II stimulated by hCG; however, captopril affected neither the ovulatory efficiency nor prostaglandin production in ovaries treated with hCG. Captopril significantly inhibited the resumption of meiosis in the ovulated ova and follicular oocytes stimulated by hCG. The administration of 100 micrograms Ang II at 2-h intervals to the perfusate reversed the inhibitory effects of captopril on hCG-induced oocyte maturation. In conclusion, these data indicate that gonadotropin stimulates renin-like activity and Ang II production in the rabbit ovary. Ovarian renin-angiotensin system may play an important role in the process of oocyte maturation after exposure to gonadotropin. |
| Databáze: | OpenAIRE |
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