| Autor: |
Carla A. Pascuale, Augusto Varese, Diego S. Ojeda, Marina E. Pasinovich, Laura Lopez, Andres H. Rossi, Pamela E. Rodriguez, Esteban A. Miglietta, Ignacio Mazzitelli, Facundo Di Diego Garcia, Lautaro Sanchez, Santiago Oviedo Rouco, María Mora Gonzalez Lopez Ledesma, Juan Pablo Zurano, Bianca Mazzitelli, Graciela Scruzzi, Paula Barbero, Diego Cardozo, Sandra Gallego, Mariel Borda, Miguel Diaz, Francisco Ridao, Angela Brigido Rosales, Jorge Bhon, Juan M. Talia, María E. Diangelo, María A. Lacaze, Balanzino Aime, Sebastian Isaac Gutierrez, Regina Ercole, Rosana Toro, Lorena Tau, Laura Delaplace, Malena Ferreyra Compagnucci, Celeste Sartori, Isabel Desimone, Cecilia Echegoyen, Pilar Velazquez, Clarisa Testa, Daniela Hozbor, Guillermo Docena, Carlos H. Laino, Nicolas Kreplak, Marina Pifano, Gabriela Barbas, Analía Rearte, Carla Vizzotti, Juan M. Castelli, Jorge Geffner, Andrea V. Gamarnik |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cell reports. Medicine. 3(8) |
| ISSN: |
2666-3791 |
| Popis: |
Heterologous vaccination against coronavirus disease 2019 (COVID-19) provides a rational strategy to rapidly increase vaccination coverage in many regions of the world. Although data regarding messenger RNA (mRNA) and ChAdOx1 vaccine combinations are available, there is limited information about the combination of these platforms with other vaccines widely used in developing countries, such as BBIBP-CorV and Sputnik V. Here, we assess the immunogenicity and reactogenicity of 15 vaccine combinations in 1,314 participants. We evaluate immunoglobulin G (IgG) anti-spike response and virus neutralizing titers and observe that a number of heterologous vaccine combinations are equivalent or superior to homologous schemes. For all cohorts in this study, the highest antibody response is induced by mRNA-1273 as the second dose. No serious adverse events are detected in any of the schedules analyzed. Our observations provide rational support for the use of different vaccine combinations to achieve wide vaccine coverage in the shortest possible time. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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