Hyaluronan-coated Prussian blue nanoparticles relieve LPS-induced peritonitis by suppressing oxidative species generation in tissue-resident macrophages

Autor:	Ansuja Pulickal Mathew, Santhosh Kalash Rajendrakumar, Adityanarayan Mohapatra, Arathy Vasukutty, Vishnu Revuri, Jagannath Mondal, Yong-Kyu Lee, Jae Young Lee, In-Kyu Park
Rok vydání:	2022
Předmět:	Lipopolysaccharides Mice Oxidative Stress Macrophages Biomedical Engineering Animals Nanoparticles General Materials Science Hydrogen Peroxide Hyaluronic Acid Peritonitis Ferrocyanides
Zdroj:	Biomaterials science. 10(5)
ISSN:	2047-4849
Popis:	Excessive inflammatory response during sepsis causes irreversible damage to healthy tissues and results in multi-organ failure. During infection, bacterial endotoxin-triggered inflammatory responses in macrophages facilitate the recruitment of circulating leukocytes, including neutrophils and monocytes. A key component that aggravates the systemic inflammatory response is the generation of stable reactive oxygen species such as hydrogen peroxide (H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b1cc623c0825a8f6ac670a8257223f https://pubmed.ncbi.nlm.nih.gov/35079755 Zobrazit plný text záznamu