Longitudinal studies of functional magnetic resonance imaging in first-episode psychosis: A systematic review
| Autor: | Benedicto Crespo-Facorro, Olga Sparano, Julio Sanjuán, Pau Soldevila-Matías, André Aleman, Luis Martí-Bonmatí, Carlos González-Vivas, Gracián García-Martí |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty ANTIPSYCHOTIC TREATMENT Prefrontal Cortex Neuroimaging Review EARLY INTERVENTION Hippocampus 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation MEDICATION CONNECTIVITY Cortex (anatomy) SCHIZOPHRENIA medicine Humans Longitudinal Studies Prefrontal cortex Anterior cingulate cortex TREATMENT RESPONSE Brain Mapping medicine.diagnostic_test business.industry ABERRANT SALIENCE fMRI Brain medicine.disease FEP Amygdala Magnetic Resonance Imaging STATE 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Psychotic Disorders Schizophrenia Posterior cingulate Longitudinal Female business Functional magnetic resonance imaging FOLLOW-UP 030217 neurology & neurosurgery Antipsychotic Agents |
| Zdroj: | European psychiatry : the journal of the Association of European Psychiatrists. 59 |
| ISSN: | 1778-3585 0924-9338 |
| Popis: | Background:Little is known about changes in brain functioning after first-episode psychosis (FEP). Such knowledge is important for predicting the course of disease and adapting interventions. Functional magnetic resonance imaging has become a promising tool for exploring brain function at the time of symptom onset and at follow-up.Method:A systematic review of longitudinal fMRI studies with FEP patients according to PRISMA guidelines. Resting-state and task-activated studies were considered together.Results:Eleven studies were included. These reported on a total of 236 FEP patients were evaluated by two fMRI scans and clinical assessments. Five studies found hypoactivation at baseline in prefrontal cortex areas, two studies found hypoactivation in the amygdala and hippocampus, and three others found hypoactivation in the basal ganglia. Other hypoactivated areas were the anterior cingulate cortex, thalamus and posterior cingulate cortex. Ten out of eleven studies reported (partial) normalization by increased activation after antipsychotic treatment. A minority of studies observed hyperactivation at baseline.Conclusions:This review of longitudinal FEP samples studies reveals a pattern of predominantly hypoactivation in several brain areas at baseline that may normalize to a certain extent after treatment. The results should be interpreted with caution given the small number of studies and their methodological and clinical heterogeneity. |
| Databáze: | OpenAIRE |
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