Genetic modifiers of rodent animal models: the role in cataractogenesis
| Autor: | Yoshiaki Kikkawa, Shumpei P. Yasuda, Kenta Wada |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Rodent genetic structures mouse model Rat model Review Bioinformatics General Biochemistry Genetics and Molecular Biology Eye injuries lens transparency 03 medical and health sciences Mice 0302 clinical medicine biology.animal medicine Animals Ocular disease Lens transparency genetic modifier General Veterinary biology business.industry Genetic heterogeneity rat model General Medicine medicine.disease eye diseases Rats Disease Models Animal 030104 developmental biology cataract Animal Science and Zoology sense organs business 030217 neurology & neurosurgery |
| Zdroj: | Experimental Animals |
| ISSN: | 1881-7122 |
| Popis: | Visual impairment leads to a decrease in quality of life. Cataract is the most commonly observed ocular disease in humans that causes vision disorders. The risk factors associated with cataract development include aging, infections, eye injuries, environmental causes, such as radiation and exposure to ultraviolet rays in sunlight, and genetic mutations. Additionally, several cataract patients display phenotypic heterogeneity, suggesting the role of genetic modifiers in the modulation of severity and onset time of cataractogenesis. However, the genetic modifiers associated with cataract have not been identified in humans yet. In contrast, the identification and mapping of genetic modifiers have been successfully carried out in mice and rats. In this review, we focus on the genetic modifiers of cataract in the rodent models. |
| Databáze: | OpenAIRE |
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