Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients
| Autor: | Nils Lachmann, Bernd Jahrsdörfer, Hubert Schrezenmeier, Linda Marie Laura Thole, Diana Stauch, Andreas Diefenbach, Tomasz Zemojtel, Katharina Jechow, Sören Lukassen, Alexander Potekhin, Katja Kotsch, Mira Choi, Yasmin Bergmann, Vanessa Proß, Oliver Hölsken, Ulrike Weber, Christian Conrad, Fabian Halleck, Caroline Tizian, Eva Schrezenmeier, Klemens Budde, Elena Storz, Friederike Bachmann, Henriette Straub-Hohenbleicher, Arne Sattler |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cellular immunity T cell medicine.medical_treatment 030232 urology & nephrology 03 medical and health sciences 0302 clinical medicine Immunity Medicine Seroconversion Dialysis Kidney transplantation 030304 developmental biology 0303 health sciences business.industry General Medicine T helper cell Acquired immune system medicine.disease 3. Good health Vaccination 030104 developmental biology medicine.anatomical_structure Immunization 030220 oncology & carcinogenesis Immunology Hemodialysis business |
| Zdroj: | Journal of Clinical Investigation |
| ISSN: | 1558-8238 |
| DOI: | 10.1172/jci150175 |
| Popis: | Novel mRNA-based vaccines have been proven powerful tools to combat the global pandemic caused by SARS-CoV2 with BNT162b2 efficiently protecting individuals from COVID-19 across a broad age range. Still, it remains largely unknown how renal insufficiency and immunosuppressive medication affect development of vaccine induced immunity. We therefore comprehensively analyzed humoral and cellular responses in kidney transplant recipients after prime-boost vaccination with BNT162b2. As opposed to all healthy vaccinees and the majority of hemodialysis patients, only 4/39 and 1/39 transplanted individuals showed IgA and IgG seroconversion at day 8±1 after booster immunization with minor changes until day 23±5, respectively. Although most transplanted patients mounted spike-specific T helper cell responses, frequencies were significantly reduced compared to controls and dialysis patients, accompanied by a broad impairment in effector cytokine production, memory differentiation and activation-related signatures. Spike-specific CD8+ T cell responses were less abundant than their CD4+ counterparts in healthy controls and hemodialysis patients and almost undetectable in transplant patients. Signs of alloreactivity promoted by BNT162b2 were not documented within the observation period. In summary, our data strongly suggest revised vaccination approaches in immunosuppressed patients, including individual immune monitoring for protection of this vulnerable group at risk to develop severe COVID-19. |
| Databáze: | OpenAIRE |
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