Fast Neutron Radiotherapy for Locally Advanced Prostate Cancer
| Autor: | J. M. Krall, L. W. Davis, M. H. Maor, George E. Laramore, K. L. Martz, F. J. Thomas, F. R. Hendrickson, Kenneth J. Russell, Thomas W. Griffin |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Prognostic variable medicine.medical_treatment Locally advanced Adenocarcinoma Fast neutron radiotherapy law.invention Fast Neutrons Prostate cancer Randomized controlled trial law Prostate Internal medicine medicine Humans Radiotherapy business.industry Prostatic Neoplasms medicine.disease Survival Analysis Radiation therapy medicine.anatomical_structure Nuclear medicine business |
| Zdroj: | American Journal of Clinical Oncology. 16:164-167 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/00000421-199304000-00018 |
| Popis: | Between June 1977 and April 1983 the Radiation Therapy Oncology Group (RTOG) sponsored a Phase III randomized trial investigating the use of fast neutron radiotherapy for patients with locally advanced (Stages C and D1) adenocarcinoma of the prostate gland. Patients were randomized to receive either conventional photon radiation or fast neutron radiation used in a mixed-beam (neutron/photon) treatment schedule. A total of 91 analyzable patients were entered into the study, and the two patient groups were balanced with respect to the major prognostic variables. Actuarial curves are presented for local/regional control and "overall" survival. Ten-year results for clinically assessed local control are 70% for the mixed-beam group versus 58% for the photon group (p = 0.03) and for survival are 46% for the mixed-beam group versus 29% for the photon group (p = 0.04). This study suggests that a regional method of treatment can influence both local tumor control and survival in patients with locally advanced adenocarcinoma of the prostate gland. |
| Databáze: | OpenAIRE |
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