Alpha-2 macroglobulin I1000V polymorphism in Chinese sporadic Alzheimer's disease and Parkinson's disease
| Autor: | Yixin Hao, Yinyu Wang, Lishan Chen, Daming Ren, Lin Xu, Hui-jun Xie, Guomei Tang, Hekui Lan, Sanduo Jiang, Dayu Lin, Mingyuan Zhang, Zucheng Wang |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male China medicine.medical_specialty Pathology Parkinson's disease Genotype DNA Mutational Analysis Gastroenterology Central nervous system disease Degenerative disease Gene Frequency Alzheimer Disease Risk Factors Internal medicine Humans Medicine Genetic Predisposition to Disease alpha-Macroglobulins Genetic Testing Aged Polymorphism Genetic business.industry General Neuroscience Genetic Variation Parkinson Disease Odds ratio Middle Aged medicine.disease Macroglobulin Female Age of onset Alzheimer's disease business |
| Zdroj: | Neuroscience Letters. 328:195-197 |
| ISSN: | 0304-3940 |
| Popis: | Several lines of evidence have revealed some overlapping pathologies in Alzheimer's disease (AD) and Parkinson's disease (PD). Although the alpha-2 macroglobulin gene (A2M) might be a risk factor of these two neurodegenerative diseases, conclusions from different studies have remained conflicting. Here we studied the role of A2M I1000V polymorphism in both AD and PD in a Chinese Han population. We found that the A2M I/V genotype is associated with both AD (odds ratio (OR)=2.55, 95% confidential interval (95% CI): 1.20–5.43, attributable fraction (AF)=13.65%) and PD (OR=3.03, 95% CI: 1.30–7.02, AF=16.51%). After classifying according to the age of onset, this association is only detected in early-onset AD patients (OR=3.96, 95% CI: 1.28–12.26) and late-onset PD patients (OR=2.61, 95% CI: 0.97–7.09). Therefore, we conclude that in our samples, the A2M I/V genotype might be a susceptibility variant, even with minor effect, for both sporadic AD and PD. |
| Databáze: | OpenAIRE |
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