Two dechlorinated chlordecone derivatives formed by in situ chemical reduction are devoid of genotoxicity and mutagenicity and have lower proangiogenic properties compared to the parent compound

Autor: Sébastien Bristeau, Sébastien Faure, Samuel Legeay, Pierre-André Billat, Christophe Mouvet, Nicolas Clere, Fabrice Nesslany
Přispěvatelé: Université d'Angers (UA), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), The results presented here were obtained through financing by the French Ministry of Environment, General Directorate for Risk Prevention (action F of the 2015 grant program MEDDE/BRGM).
Rok vydání: 2016
Předmět:
0301 basic medicine
Salmonella
Insecticides
MESH: Chlordecone/analysis
Angiogenesis
Health
Toxicology and Mutagenesis
MESH: DNA Damage/genetics
In situ chemical reduction
MESH: Mutagenicity Tests
010501 environmental sciences
medicine.disease_cause
01 natural sciences
Mutagenicity
MESH: Mutagens/toxicity
Organic chemistry
Soil Pollutants
MESH: Mutagenesis
Chemistry
Lymphoblast
MESH: Insecticides/analysis
MESH: Chlordecone/chemistry
General Medicine
respiratory system
Pollution
3. Good health
Chlordecone
[SDV.TOX]Life Sciences [q-bio]/Toxicology
congenital
hereditary
and neonatal diseases and abnormalities
MESH: Soil Pollutants/chemistry
MESH: Insecticides/chemistry
03 medical and health sciences
medicine
Environmental Chemistry
Humans
0105 earth and related environmental sciences
MESH: Humans
Mutagenicity Tests
Neurotoxicity
medicine.disease
Molecular biology
In vitro
respiratory tract diseases
030104 developmental biology
Mutagenesis
Dechlorination
Genotoxicity
Micronucleus
MESH: Soil Pollutants/analysis
DNA Damage
Mutagens
Zdroj: Environmental Science and Pollution Research
Environmental Science and Pollution Research, 2018, 25 (15), pp.14313-14323. ⟨10.1007/s11356-017-8592-6⟩
Environmental Science and Pollution Research, Springer Verlag, 2018, 25 (15), pp.14313-14323. ⟨10.1007/s11356-017-8592-6⟩
ISSN: 1614-7499
0944-1344
DOI: 10.1007/s11356-017-8592-6⟩
Popis: International audience; Chlordecone (CLD) is a chlorinated hydrocarbon insecticide, now classified as a persistent organic pollutant. Several studies have previously reported that chronic exposure to CLD leads to hepatotoxicity, neurotoxicity, raises early child development and pregnancy complications, and increases the risk of liver and prostate cancer. In situ chemical reduction (ISCR) has been identified as a possible way for the remediation of soils contaminated by CLD. In the present study, the objectives were (i) to evaluate the genotoxicity and the mutagenicity of two CLD metabolites formed by ISCR, CLD-5a-hydro, or CLD-5-hydro (5a- or 5- according to CAS nomenclature; CLD-1Cl) and tri-hydroCLD (CLD-3Cl), and (ii) to explore the angiogenic properties of these molecules. Mutagenicity and genotoxicity were investigated using the Ames's technique on Salmonella typhimurium and the in vitro micronucleus micromethod with TK6 human lymphoblastoid cells. The proangiogenic properties were evaluated on the in vitro capillary network formation of human primary endothelial cells. Like CLD, the dechlorinated derivatives of CLD studied were devoid of genotoxic and mutagenic activity. In the assay targeting angiogenic properties, significantly lower microvessel lengths formed by endothelial cells were observed for the CLD-3Cl-treated cells compared to the CLD-treated cells for two of the three tested concentrations. These results suggest that dechlorinated CLD derivatives are devoid of mutagenicity and genotoxicity and have lower proangiogenic properties than CLD.
Databáze: OpenAIRE
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