Specificity of oral immune priming in the red flour beetle Tribolium castaneum
| Autor: | Marie P. Sell, Joachim Kurtz, Megan A. M. Kutzer, Momir Futo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Innate immune system biology Toxin fungi biology.organism_classification medicine.disease_cause Agricultural and Biological Sciences (miscellaneous) Microbiology 03 medical and health sciences 030104 developmental biology Immune system innate immunity specific immune memory invertebrate immune priming Bacillus thuringiensis Tribolium castaneum Antigen medicine Red flour beetle General Agricultural and Biological Sciences Pathogen Priming (psychology) |
| Zdroj: | Biology Letters |
| Popis: | Immune specificity is the degree to which a host's immune system discriminates among various pathogens or antigenic variants. Vertebrate immune memory is highly specific due to antibody responses. On the other hand, some invertebrates show immune priming, i.e. improved survival after secondary exposure to a previously encountered pathogen. Until now, specificity of priming has only been demonstrated via the septic infection route or when live pathogens were used for priming. Therefore, we tested for specificity in the oral priming route in the red flour beetle, Tribolium castaneum . For priming, we used pathogen-free supernatants derived from three different strains of the entomopathogen, Bacillus thuringiensis , which express different Cry toxin variants known for their toxicity against this beetle. Subsequent exposure to the infective spores showed that oral priming was specific for two naturally occurring strains, while a third engineered strain did not induce any priming effect. Our data demonstrate that oral immune priming with a non-infectious bacterial agent can be specific, but the priming effect is not universal across all bacterial strains. |
| Databáze: | OpenAIRE |
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