High-level SETD1B gene expression is associated with unfavorable prognosis in hepatocellular carcinoma
Autor: | Guanglin Lei, Shaogeng Zhang, Dong Chen, Wang Ruilan, Xiliang Wang, Tieling Li, Linxiang Yu, Jin Yan, Penghui Yang, Zhaohai Wang, Peirui Zhang, Cheng Wang |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Cancer Research Carcinoma Hepatocellular SET domain-containing 1B Biochemistry Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Gene expression Genetics medicine Carcinoma Biomarkers Tumor Humans Molecular Biology Aged Proportional Hazards Models Regulation of gene expression Oncogene business.industry Liver Neoplasms Cancer Articles hepatocellular carcinoma Hep G2 Cells Histone-Lysine N-Methyltransferase Middle Aged medicine.disease Prognosis Molecular medicine digestive system diseases Gene Expression Regulation Neoplastic 030104 developmental biology Real-time polymerase chain reaction Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Molecular Medicine Female business |
Zdroj: | Molecular Medicine Reports |
ISSN: | 1791-3004 1791-2997 |
Popis: | The SET domain-containing 1B (SETD1B) gene is involved in multiple biological processes, including tumor development and progression. However, the role of SETD1B in hepatocellular carcinoma (HCC) is largely unexplored. The present study, examined the expression of SETD1B in patients with HCC and assessed its clinical significance. Reverse transcriptase quantitative polymerase chain reaction and western blot analysis results revealed that the expression levels of SETD1B mRNA and protein were significantly increased in HCC tumor tissues compared with the adjacent normal tissues. In addition, an analysis of the patient clinical factors indicated that increased levels of SETD1B expression were associated with tumor size, clinical stage and liver cirrhosis. Patients with HCC with decreased levels of SETD1B expression exhibited longer survival times compared with those with increased levels of SETD1B expression. In addition, Cox's regression analysis results implied that the upregulation of SETD1B was an independent prognostic marker in patients with HCC. Taken together, the results demonstrated that SETD1B is essential in the progression of HCC and may be used as a potential prognostic marker and therapeutic target in HCC. |
Databáze: | OpenAIRE |
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