The within-host fitness of HIV-1 increases with age in ART-naïve HIV-1 subtype C infected children
| Autor: | Anita Shet, Bindu Parachalil Gopalan, Pradeep Nagaraja, Reena R. D’Souza, Narendra M. Dixit, Debolina Sarkar, Niharika Rajnala |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Male Adolescent Science Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Immune system Antiretroviral Therapy Highly Active HIV Seropositivity Medicine Computational models Humans 030212 general & internal medicine Permissive Child Multidisciplinary Cd4 t cell business.industry Host (biology) Infant Newborn Infant Viral Load CD4 Lymphocyte Count 030104 developmental biology Viral dynamics Anti-Retroviral Agents Child Preschool Immunology HIV-1 Female Genetic Fitness business Basic reproduction number Viral load |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| Popis: | As the immune system develops with age, children combat infections better. HIV-1, however, targets an activated immune system, potentially rendering children increasingly permissive to HIV-1 infection as they grow. How HIV-1 fitness changes with age in children is unknown. Here, we estimated the within-host basic reproductive ratio, R0, a marker of viral fitness, in HIV-1 subtype C-infected children in India, aged between 84 days and 17 years. We measured serial viral load and CD4 T cell counts in 171 children who initiated first-line ART. For 25 children, regular and frequent measurements provided adequate data points for analysis using a mathematical model of viral dynamics to estimate R0. For the rest, we used CD4 counts for approximate estimation of R0. The viral load decline during therapy was biphasic. The mean lifespans of productively and long-lived infected cells were 1.4 and 27.8 days, respectively. The mean R0 was 1.5 in children aged R0 is small, will likely improve viral control, in addition to suppressing the latent reservoir. |
| Databáze: | OpenAIRE |
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