Lack of Influence of Hepatitis G Virus Infection on Alcohol-Related Hepatic Lesions
| Autor: | P. Rampal, G. Yang, R. Follana, J. Durant, A. Doglio, F. Longo, Sylvia Benzaken, D. Ouzan, Martin Buckley, P. Hastier, Albert Tran, Marie-Christine Saint-Paul |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Cirrhosis Hepatitis Viral Human Population Gastroenterology Virus Serology Seroepidemiologic Studies Internal medicine medicine Humans Seroprevalence Viremia Risk factor education Liver Diseases Alcoholic education.field_of_study Reverse Transcriptase Polymerase Chain Reaction business.industry Flaviviridae Middle Aged medicine.disease Case-Control Studies Immunology Female Viral disease business Viral hepatitis |
| Zdroj: | Scandinavian Journal of Gastroenterology. 33:1209-1212 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.1080/00365529850172584 |
| Popis: | The purposes of this study were to analyse the prevalence and histologic impact of hepatitis G virus (HGV), a newly discovered virus, in alcoholic patients, a population known to be at risk for viral hepatitis.One hundred and thirty-nine consecutive alcoholics admitted to our liver unit (106 men and 33 women; mean age, 47.1 +/- 10.9 years) were included in the study. All patients had consumed more than 60 g of ethanol per day for at least 1 year. One hundred healthy blood donors constituted a control group. Antibodies to HGV E2 protein and HGV-RNA testing by reverse transcription-polymerase chain reaction (RT-PCR) with primers derived from the NS5 coding region were performed in all serum samples.A significantly higher seroprevalence of anti-E2 antibodies was observed in alcoholic patients than in healthy blood donors (41 (29.5%) versus 8 (8%); P0.0001). Moreover, the prevalence of HGV-RNA was significantly higher in alcoholic patients (13 (9.3%) versus 1 (1%); P = 0.01). HGV-RNA and anti-HGV antibodies were never detected simultaneously. HGV viraemia was not associated with an increased risk of cirrhosis or hepatocarcinoma in alcoholic subjects.Our study reports a high prevalence of HGV in alcoholic patients. HGV infection does not modify or aggravate the course of alcoholic liver disease. |
| Databáze: | OpenAIRE |
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