TDP‐43 pathology effect on volume and flortaucipir uptake in Alzheimer's disease
| Autor: | Arenn F. Carlos, Nirubol Tosakulwong, Stephen D. Weigand, Matthew L. Senjem, Christopher G. Schwarz, David S. Knopman, Bradley F. Boeve, Ronald C. Petersen, Aivi T. Nguyen, R. Ross Reichard, Dennis W. Dickson, Clifford R. Jack, Val Lowe, Jennifer L. Whitwell, Keith A. Josephs |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Alzheimer's & Dementia. |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | Alzheimer's disease (AD) patients ≥70 years show smaller medial temporal volumes despite lessSeventy-seven participants with flortaucipir-PET and volumetric magnetic resonance imaging underwent postmortem AD and TDP-43 pathology assessments. Bivariate-response linear regression estimated the effect of age and TDP-43 pathology on volume and/or flortaucipir standardized uptake volume ratios of the hippocampus, amygdala, entorhinal, inferior temporal, and midfrontal cortices.Older participants had lower hippocampal volumes and overall flortaucipir uptake. TDP-43-immunoreactivity correlated with reduced medial temporal volumes but was unrelated to flortaucipir uptake. TDP-43 effect size was consistent across the age spectrum. However, at older ages, the cohort mean volumes moved toward those of TDP-43-positives, reflecting the increasing TDP-43 pathology frequency with age.TDP-43 pathology is a relevant contributor driving the volume-uptake mismatch in older AD participants.TDP-43 pathology affects medial temporal volume loss but not tau radiotracer uptake. Greater TDP-43 pathology effect is seen in old age due to its increasing frequency. TDP-43 pathology is a relevant driver of the volume-uptake mismatch in old AD patients. |
| Databáze: | OpenAIRE |
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