Teriparatide Improves Bone and Lipid Metabolism in a Male Rat Model of Type 2 Diabetes Mellitus
Autor: | Momoko Nakatsugawa, Hirotoshi Utsunomiya, Akihiko Tokuda, Aya Takakura, Yukihiro Isogai, Misa Nakamura, Ryoko Takao-Kawabata, Ryohei Kono, Akihiro Maeno, Toshinori Ishizuya, Akihiro Kitami, Sachiko Nomura |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Blood Glucose Male medicine.medical_specialty Parathyroid Bone and Mineral Metabolism medicine.medical_treatment Osteoporosis 030209 endocrinology & metabolism Bone and Bones Bone remodeling 03 medical and health sciences 0302 clinical medicine Endocrinology Osteoclast Bone Density Elcatonin Internal medicine Teriparatide medicine Animals RNA Messenger Research Articles Bone mineral business.industry Rats Inbred Strains Bisphosphonate medicine.disease Lipid Metabolism Rats 030104 developmental biology medicine.anatomical_structure Glucose Diabetes Mellitus Type 2 Gene Expression Regulation Liver Cortical bone business medicine.drug |
Zdroj: | Endocrinology |
ISSN: | 1945-7170 |
Popis: | Osteoporosis is a complication of diabetes mellitus (DM). The pathology of diabetic osteoporosis is distinct from postmenopausal osteoporosis, and there are no specific treatment guidelines for diabetic osteoporosis. In the current study, this issue was addressed by evaluating the effect of osteoporosis medications, such as the anabolic agent PTH [teriparatide (TPTD)] and the antiresorptive agents calcitonin [elcatonin (ECT)] and bisphosphonate [risedronate (RIS)], on bone metabolism as well as on glucose and lipid metabolism in spontaneously diabetic Torii (SDT) fatty rats, which are a model of type 2 DM (T2DM). The medicines were injected subcutaneously into 8-week-old male SDT fatty rats three times weekly for 8 weeks. TPTD treatment in SDT fatty rats increased the osteoblast number and function on trabecular bone in vertebrae, and increased the trabecular bone mass, bone mineral density (BMD), and mechanical strength of vertebrae. Additionally, TPTD improved cortical bone structure and increased BMD. RIS decreased the osteoclast number and function, which led to an increase in vertebral bone mineral content and BMD in the femoral diaphysis, and mechanical strength was increased in the vertebrae. ECT showed no clear effects on bone mass or metabolism. Similar to diabetic lesions, all of the drugs had no effects on hyperglycemia, pancreas morphology, or serum insulin and glucagon levels. However, triglyceride levels and lipid droplets in fatty liver were decreased in the TPTD group. These results suggest that TPTD may be useful for treating fatty liver in addition to osteoporosis in T2DM. |
Databáze: | OpenAIRE |
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