Resolution of psoriasis after allogeneic bone marrow transplantation for chronic myelogenous leukemia: late complications of therapy
| Autor: | Ravi Vij, Muneer H. Abidi, Peter Westervelt, Lawrence T. Goodnough, H Khoury, Douglas Adkins, John F. DiPersio, R Brown |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Graft vs Host Disease chemical and pharmacologic phenomena Disease Autoimmune Diseases Quality of life immune system diseases hemic and lymphatic diseases Psoriasis Internal medicine Immunopathology Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Bone Marrow Transplantation Autoimmune disease Transplantation business.industry Hematology Middle Aged medicine.disease Surgery surgical procedures operative medicine.anatomical_structure Chronic Disease Female Bone marrow Complication business Chronic myelogenous leukemia |
| Zdroj: | Bone marrow transplantation. 26(11) |
| ISSN: | 0268-3369 |
| Popis: | Treatment of autoimmune disease with bone marrow transplantation (BMT) is under investigation. A few reports of patients undergoing allogeneic BMT for malignant conditions observed the resolution of psoriasis after BMT, with minimal late morbidity. We describe a patient with chronic myelogenous leukemia (CML) whose psoriasis resolved completely after allogeneic BMT. However, the patient's course was complicated by extensive chronic graft-versus-host disease (GVHD), recurrent serious infections, poor performance status and quality of life, and severe disability. The patient died 887 days post transplant due to infectious complications. The potential benefits and risks of treatment of autoimmune diseases with allogeneic BMT are discussed. |
| Databáze: | OpenAIRE |
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