Natural clearance of hepatitis C virus in hemophilia patients
Autor: | Gunta Chernevska, Zhanna Kovalova, Arturs Sochnevs, Jelena Eglite, Velga Kuse, Sandra Lejniece, Raimonds Simanis, Dace Gardovska, Agita Jeruma, Ludmila Viksna |
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Jazyk: | angličtina |
Rok vydání: | 2007 |
Předmět: |
Adult
Male hepatitis C virus Adolescent Genotype Hepatitis C virus Genes MHC Class II Enzyme-Linked Immunosorbent Assay Hepacivirus Human leukocyte antigen Hemophilia A medicine.disease_cause Polymerase Chain Reaction Virus law.invention HLA Antigens law human leukocyte antigen hemophilia Prevalence Humans Medicine Allele Child Allele frequency Polymerase chain reaction Chi-Square Distribution biology business.industry Age Factors Healthy subjects virus diseases Lithuania General Medicine Hepatitis C Latvia United States digestive system diseases natural clearance Data Interpretation Statistical Immunology biology.protein RNA Viral Antibody business |
Zdroj: | Medicina; Volume 44; Issue 1; Pages: 15 Scopus-Elsevier Medicina Volume 44 Issue 1 |
ISSN: | 1648-9144 |
DOI: | 10.3390/medicina44010003 |
Popis: | Objective. The objective of this study was to investigate the prevalence of HCV (hepatitis C virus) infection in hemophilia patients in Latvia and to analyze association between natural clearance of HCV and human leukocyte antigen (HLA) class II genes. Material and methods. From 61 hemophilic patients participating in this study, 38 were adults and 23 were pediatric patients younger than 18 years. To analyze association between HLA class II alleles and natural clearance of HCV, the gene frequency was compared in hemophilia patients group and the control group of 60 healthy subjects, all men. Serum HCV RNA was qualitatively determined and HLA class II alleles were identified by polymerase chain reaction (PCR) method. Results. HCV infection is common among hemophilia patients in Latvia. Antibodies to HCV were found in 45 of 61 (74%) hemophilia patients. In 41% of hemophilia patients (18 of 44), HCV infection resolved spontaneously. Children cleared HCV more frequently than adults (7 of 11 comparing to 11 of 33, respectively OR=3.50 P< 0.05). The frequency difference was found to be statistically significant when comparing HLA alleles distribution in the sample of hemophilia patients who naturally cleared HCV (n=18) and in the control group (n=60) (corresponding frequency of HLA-DRB1*07 allele – 4 (11.11%) and 9 (1.67%) OR=7.38 0.05). Conclusions. Natural clearance of HCV infection is frequently found in hemophilia patients in Latvia. Children are more likely to clear virus naturally than adults. There is an association between natural clearance of HCV and HLA allele DRB1*07 in hemophilia patients. |
Databáze: | OpenAIRE |
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