A 3D-printed modular magnetic digital microfluidic architecture for on-demand bioanalysis
Autor: | Shilun Feng, Shawn Vasoo, Ai Qun Liu, Aiwu Zhou, Pojchanun Kanitthamniyom, Yi Zhang |
---|---|
Přispěvatelé: | School of Electrical and Electronic Engineering, School of Mechanical and Aerospace Engineering, Singapore Centre for 3D Printing |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Bioanalysis
Computer science Materials Science (miscellaneous) Microfluidics 02 engineering and technology Substrate (printing) Hardware_PERFORMANCEANDRELIABILITY 01 natural sciences lcsh:Technology Industrial and Manufacturing Engineering Component (UML) Hardware_INTEGRATEDCIRCUITS Fluidics Digital microfluidics Electrical and Electronic Engineering Architecture Hardware_ARITHMETICANDLOGICSTRUCTURES business.industry lcsh:T 010401 analytical chemistry Modular design 021001 nanoscience & nanotechnology Condensed Matter Physics Atomic and Molecular Physics and Optics 0104 chemical sciences Biosensors lcsh:TA1-2040 Embedded system Mechanical engineering [Engineering] 0210 nano-technology business lcsh:Engineering (General). Civil engineering (General) |
Zdroj: | Microsystems & Nanoengineering, Vol 6, Iss 1, Pp 1-11 (2020) |
ISSN: | 2055-7434 |
Popis: | Magnetic digital microfluidics (MDM) manipulates fluids in the form of droplets on an open substrate, and incorporates surface energy traps (SETs) to facilitate the droplet manipulation. Conventional MDM devices are fabricated monolithically, which makes it difficult to modify the device configuration without completely overhauling the original design. In this paper, we present a modular MDM architecture that enables rapid on-demand configuration and re-configuration of MDM platforms for customized bioanalyses. Each modular component contains a SET and a Lego-like antistud that fits onto a base board with Lego-like studs. We illustrate the versatility of the modular MDM architecture in biomarker sensing, pathogen identification, antibiotic resistance determination, and biochemical quantification by demonstrating immunoassays, phenotypical assays and enzymatic assays on various modular MDM platforms configured on demand to accomplish the fluidic operations required by assorted bioanalytical assays. The modular MDM architecture promises great potential for point-of-care diagnostics by offering on-demand customization of testing platforms for various categories of diagnostic assays. It also provides a new avenue for microfluidic assay development with its high configurability which would significantly reduce the time and cost of the development cycle. A Lego-inspired, modular magnetic digital microfluidic architecture enables customizable bioanalysis. Magnetic digital microfluidics controls droplets on a surface via magnetic particles, with the liquid droplets themselves acting as mini bioreactors for analysis. Such devices often include surface energy traps to aide droplet manipulation. However, because they are fabricated as monolithic systems, they cannot be altered for different bioanalysis post-fabrication. Here, a team led by Yi Zhang from Nanyang Technological University, Singapore, reports a modular design for magnetic digital microfluidic devices, in which functional modules are configured and reconfigured via Lego-like studs. This modular design allows users to build testing platform on demand for a wide range of bioanalyses. |
Databáze: | OpenAIRE |
Externí odkaz: |