Assessment of programmed death-ligand 1 receptor immunohistochemical expression and its association with tumor-infiltrating lymphocytes and p53 status in triple-negative breast cancer
| Autor: | Liliana-Ana Tuţă, Antonela Anca Nicolau, Mariana Aşchie, Mariana Deacu, Gabriela Izabela Bălţătescu, Anca Florentina Mitroi, Mădălina Boşoteanu, Lucian Cristian Petcu, Oana Cojocaru, Manuela Enciu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
PD-L1 p53 Oncology Embryology medicine.medical_specialty Lymphovascular invasion Breast Neoplasms Triple Negative Breast Neoplasms B7-H1 Antigen Pathology and Forensic Medicine Lymphocytes Tumor-Infiltrating Breast cancer Internal medicine Biomarkers Tumor Tumor Microenvironment Adjuvant therapy Humans Medicine Lung cancer Triple-negative breast cancer Original Paper Tumor microenvironment business.industry Tumor-infiltrating lymphocytes Cancer Cell Biology General Medicine Prognosis medicine.disease tumor-infiltrating lymphocytes immunohistochemistry triple-negative breast cancer Female Tumor Suppressor Protein p53 business Developmental Biology |
| Zdroj: | Romanian Journal of Morphology and Embryology |
| ISSN: | 2066-8279 1220-0522 |
| Popis: | Breast cancer (BC) is the second most frequent type of cancer for both sexes combined, after lung cancer. Triple-negative BC (TNBC) molecular subtype is characterized by lack of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) immunoexpression or amplification and represent 10–20% of all BC cases. The issue of the present study was to analyze the associations between programmed death-ligand 1 (PD-L1) immunoexpression and distribution of stromal tumor-infiltrating lymphocytes (stTILs) combined with clinico-morphological features of patients with TNBC. Secondly, our research evaluated PD-L1 immunoexpression as a prognostic factor and its correlation with p53 immunoexpression. Thirty cases with primary TNBC without prior neoadjuvant therapy were included in this research. stTILs were identified in all cases, most of them with low distribution (66.7%). A positive immunoreaction for PD-L1 was observed in 40% of cases. The PD-L1 immunoexpression was statistically significant associated with age, pathological tumor size, lymphovascular invasion, stTILs level, the presence of cluster of differentiation 8-positive (CD8+) TILs and p53 immunoexpression. In the present study, a positive PD-L1 immunoexpression was associated with a worse distant metastasis free survival (DMFS). We also found not only that high stTILs level were associated with a better DMFS but also that there was a statistically significant association between stTILs level and PD-L1 immunoexpression. Our results bring new insights to the fine connections between tumor microenvironment and molecular changes of TNBC. It helps us to better understand these aggressive tumors to identify the more useful biomarkers for predicting the response to adjuvant therapy and can represent a method for selecting the most suitable patients for immunotherapy. |
| Databáze: | OpenAIRE |
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