Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients
| Autor: | Joseph H. Lee, Rando Allikmets, Juan B. Yepez, Susan S. Kim, Etienne Simon-Loriere, Anavaj Sakuntabhai, Gladys E. Maestre, Joseph D. Terwilliger, C Gustavo De Moraes, Mussaret B. Zaidi, Claude Ruffié, Michele Pettito, Matthieu Prot |
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| Přispěvatelé: | Columbia University Medical Center (CUMC), Columbia University [New York], Clinica de Ojos de Maracaibo [Vénézuela], Génétique fonctionnelle des Maladies infectieuses - Functional Genetics of Infectious Diseases, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Hospital General Agustín O’Horán [Merida, Mexico], Michigan State University [East Lansing], Michigan State University System, Génomique virale et vaccination, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], St Peter's Hospital [Albany, NY, USA], National Institute for Health and Welfare [Helsinki], University of Zulia [Maracaibo, Venezuela], Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Universidad del Zulia (LUZ) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Microbiology (medical)
Pediatrics medicine.medical_specialty viruses Dengue virus medicine.disease_cause Microbiology Serology Zika virus Dengue fever Optic neuropathy 03 medical and health sciences 0302 clinical medicine Epidemiology medicine [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology Optic neuritis Case Series 030212 general & internal medicine optic neuritis [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] biology business.industry vision loss medicine.disease biology.organism_classification [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] dengue 3. Good health congenital glaucoma arbovirus [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Occular 030221 ophthalmology & optometry uveitis [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] business Uveitis steroid treatment |
| Zdroj: | JMM Case Reports JMM Case reports JMM Case reports, Society for General Microbiology, 2018, 5 (5), ⟨10.1099/jmmcr.0.005145⟩ JMM Case reports, 2018, 5 (5), ⟨10.1099/jmmcr.0.005145⟩ |
| ISSN: | 2053-3721 |
| DOI: | 10.1099/jmmcr.0.005145⟩ |
| Popis: | Introduction. Although the current Zika virus (ZIKV) epidemic is a major public health concern, most reports have focused on congenital ZIKV syndrome, its most devastating manifestation. Severe ocular complications associated with ZIKV infections and possible pathogenetic factors are rarely described. Here, we describe three Venezuelan patients who developed severe ocular manifestations following ZIKV infections. We also analyse their serological response to ZIKV and dengue virus (DENV). Case presentation. One adult with bilateral optic neuritis, a child of 4 years of age with retrobulbar uveitis and a newborn with bilateral congenital glaucoma had a recent history of an acute exanthematous infection consistent with ZIKV infection. The results of ELISA tests indicated that all patients were seropositive for ZIKV and four DENV serotypes. Conclusion. Patients with ZIKV infection can develop severe ocular complications. Anti-DENV antibodies from previous infections could play a role in the pathogenesis of these complications. Well-designed epidemiological studies are urgently needed to measure the risk of ZIKV ocular complications and confirm whether they are associated with the presence of anti-flaviviral antibodies. |
| Databáze: | OpenAIRE |
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