Zuclopenthixol decanoate in pregnancy: Successful outcomes in two consecutive off springs of the same mother
| Autor: | Marija Stepanović, R Dragan Milovanovic, Slavica Djukic-Dejanovic, Mirjana Varjacic, Dragan Loncar, Slobodan M. Jankovic, Slobodan Obradovic, Dejana Ruzic-Zecevic, Olivera Laban, Vladimir Janjic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Psychosis Zuclopenthixol decanoate 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine psychotic disorders Haloperidol Humans Medicine risk factors Pharmacology (medical) Psychiatry Social functioning Pregnancy lcsh:R5-920 Risperidone business.industry Infant Newborn Pregnancy Outcome First pregnancy Clopenthixol medicine.disease psychotropic drugs 3. Good health 030227 psychiatry Pregnancy Complications Schizophrenia treatment outcome Female pregnancy business lcsh:Medicine (General) Antipsychotic Agents medicine.drug |
| Zdroj: | Vojnosanitetski Pregled, Vol 70, Iss 5, Pp 526-529 (2013) |
| ISSN: | 0042-8450 |
| Popis: | Introduction. Almost all individual antipsychotics are classified into the intermediate pregnancy risk category as no or limited data exist about human pregnancy outcomes. We presented the case of zuclopenthixol decanoate using in two successive pregnancies of the same woman, which had not been published in the available peer-reviewed literature. Case report. A middle-age female subject who suffered from schizophrenia received zuclopenthixol decanoate injection during her two consecutive pregnancies. About four and a half months before diagnosis of the first pregnancy (~3.5 years after psychosis emergence), zuclopenthixol decanoate (400 mg every other week, im injection) was introduced to the treatment protocol (due to previous non-compliance with haloperidol and risperidone). A significant clinical improvement was achieved and the dose during pregnancy was reduced to 200 mg once monthly and maintained to date. In both pregnancies the women gave birth to healthy girls who have been developing normally until now, at their ages of 6 months and of 3.5 years. During pregnancy and after giving birth to children the mothers’ psychiatric status and her social functioning were significantly improved and are still stable. Close monitoring of the mother’s health, a multidisciplinary approach to both her treatment and the monitoring of pregnancies as well as the complete compliance with the prescribed drug protocol were likely to be crucial for the therapeutic success. Conclusion. A favorable outcome of the present case suggests that the zuclopenthixol decanoate is a rational therapeutic option for pregnant women suffering from psychosis when the expected benefit exceed the potential risk, but a definitive evidence for its safety requires large, controlled studies. [Projekat Ministarstva nauke Republike Srbije, br. 175014] |
| Databáze: | OpenAIRE |
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