Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia
| Autor: | Angélica María González-Clavijo, Sergio Andrés Vallejo, Elizabeth Sanchez, Martín Carlos Abba, Jorge E. Caminos, Luis G. Leal, Carlos Dieguez, Justo P. Castaño, Ezequiel Lacunza, Edith Ángel-Müller, María Fernanda Garcés, Miguel A. Palomino-Palomino, Rubén Nogueiras, Luz Amparo Díaz-Cruz, Ariel Iván Ruiz-Parra |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Follistatin Adolescent Endocrinology Diabetes and Metabolism media_common.quotation_subject Blood Pressure Enzyme-Linked Immunosorbent Assay Luteal phase Luteal Phase Preeclampsia Ciencias Biológicas Young Adult Endocrinology Pre-Eclampsia Pregnancy Internal medicine Follicular phase Medicine Humans Longitudinal Studies reproductive and urinary physiology Menstrual cycle media_common biology Anthropometry business.industry Reproduction Postpartum Period Reproducibility of Results Bioquímica y Biología Molecular medicine.disease Follicular Phase Case-Control Studies biology.protein Rat Gestation Female business human activities CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | Clinical endocrinology. 83(2) |
| ISSN: | 1365-2265 |
| Popis: | Objective: Follistatin (FST) is a regulator of the biological activity of activin A (Act A), binding and blocking it, which could contribute to the modulation of its pro-inflammatory activity during pregnancy. We sought to investigate, in this nested case–control study, FST serum levels during normal pregnancy and correlate it with the FST profile in preeclamptic pregnant women, normal pregnant women followed 3 months postpartum and eumenorrheic nonpregnant women throughout the menstrual cycle. Subjects and Methods: Follistatin serum levels determined by ELISA, biochemical and anthropometric variables were measured in normal pregnant (n = 28) and preeclamptic (n = 20) women during three periods of gestation. In addition, FST serum levels were measured in a subset of normal pregnant women (n = 13) followed 3 months postpartum and in eumenorrheic nonpregnant women (n = 20) during the follicular and luteal phases of the menstrual cycle. Results: Follistatin serum levels in the eumenorrheic nonpregnant and postpartum group were significantly lower when compared to levels throughout gestation (P < 0·01). Serum FST levels increased in each period of pregnancy analysed, being significantly higher towards the end of gestation (P < 0·01). FST levels were lower in late pregnancy in preeclamptic women compared to normal pregnant women (P < 0·05). Finally, FST levels were higher in the luteal phase when compared with the follicular phase of the menstrual cycle (P < 0·05). Conclusions: These analyses would permit the consideration that changes in FST levels during pregnancy contribute to the control of the Act A system. Fil: Garcés, María F.. Universidad Nacional de Colombia; Colombia Fil: Vallejo, Sergio A.. Universidad Nacional de Colombia; Colombia Fil: Sanchez, Elizabeth. Universidad Nacional de Colombia; Colombia Fil: Palomino Palomino, Miguel A.. Universidad Nacional de Colombia; Colombia Fil: Leal, Luis G.. Universidad Nacional de Colombia; Colombia Fil: Ángel Muller, Edith. Universidad Nacional de Colombia; Colombia Fil: Diaz Cruz, Luz A.. Universidad Nacional de Colombia; Colombia Fil: Ruíz Parra, Ariel Iván. Universidad Nacional de Colombia; Colombia Fil: González Clavijo, Angélica M.. Universidad Nacional de Colombia; Colombia Fil: Castaño, Justo P.. Universidad de Córdoba; España. CIBER de Obesidad y Nutrición; España Fil: Abba, Martín Carlos. Universidad Nacional de La Plata. Facultad de Ciencias Medicas. Centro de Investigaciones Inmunologicas Basicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Medicas. Centro de Investigaciones Inmunologicas Basicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Diéguez, Carlos. Universidad de Santiago de Compostela; España. CIBER de Obesidad y Nutrición; España Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España. CIBER de Obesidad y Nutrición; España Fil: Caminos, Jorge E.. Universidad Nacional de Colombia; Colombia |
| Databáze: | OpenAIRE |
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