Association of HLA Class-II Genes and Anti-Neutrophil Cytoplasmic Antibodies in Chinese Patients with Inflammatory Bowel Disease
| Autor: | K. N. Lai, Yuk Tong Lee, Joseph J.Y. Sung, P. Poon, Philip Kam-Tao Li |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Genotype Genes MHC Class II Human leukocyte antigen Polymerase Chain Reaction Inflammatory bowel disease Genetic determinism Antibodies Antineutrophil Cytoplasmic Gene Frequency Immunopathology medicine Humans Fluorescent Antibody Technique Indirect Gene Anti-neutrophil cytoplasmic antibody biology business.industry Gastroenterology medicine.disease Ulcerative colitis Case-Control Studies Immunology biology.protein Hong Kong Colitis Ulcerative Female Antibody business Polymorphism Restriction Fragment Length |
| Zdroj: | ResearcherID |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | Inflammatory bowel disease is common in the West but rare in China. The genetic factor predisposing to the disease is unclear. Ulcerative colitis (UC) is found to be associated with HLA DR2 alleles in the West. Subgroups of UC patients have been further defined by the presence of anti-neutrophil cytoplasmic antibodies (ANCA).We attempted to define the HLA class-II genes (DRbeta, DQalpha, DQbeta) and their relationship with ANCA in southern Chinese patients with UC. Patients were tested for class-II genes by restriction fragment length polymorphism and polymerase chain reactions. The indirect immunofluorescence test was used to detect ANCA in the sera. Ethnically matched normal controls were used for comparison.In ANCA-positive UC patients (n = 18) there was a strong association with HLA-DQalpha1c allele (P0.0001) when compared with controls (n = 104). This association was not found in ANCA-negative UC patients (n = 10) (P = 0.21).In Chinese UC patients positive ANCA is associated with the HLA-DQalpha1c allele, which is not the case in Caucasian patients. |
| Databáze: | OpenAIRE |
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