In African American Type 2 Diabetic Patients, Is Vitamin D Deficiency Associated with Lower Blood Levels of Hydrogen Sulfide and Cyclic Adenosine Monophosphate, and Elevated Oxidative Stress?
| Autor: | Lester Morehead, Pat F. Bass, Robert Hoeldtke, Sushil K. Jain, Prasenjit Manna, Benjamin J. Lieblong, Steven N. Levine, Gunjan Kahlon, David Micinski |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system diseases Physiology Clinical Biochemistry Biology medicine.disease_cause Biochemistry vitamin D deficiency chemistry.chemical_compound Internal medicine Diabetes mellitus Cyclic AMP Vitamin D and neurology medicine Humans News & Views Cyclic adenosine monophosphate Secretion Hydrogen Sulfide Molecular Biology General Environmental Science chemistry.chemical_classification Reactive oxygen species nutritional and metabolic diseases Cell Biology Middle Aged Vitamin D Deficiency equipment and supplies medicine.disease Black or African American Oxidative Stress Endocrinology Diabetes Mellitus Type 2 chemistry Cell culture General Earth and Planetary Sciences Female Reactive Oxygen Species Oxidative stress |
| Zdroj: | Antioxidants & Redox Signaling. 18:1154-1158 |
| ISSN: | 1557-7716 1523-0864 |
| DOI: | 10.1089/ars.2012.4843 |
| Popis: | African Americans (AA) have a higher incidence of cardiovascular disease and vitamin D (VD) deficiency compared with Caucasians. Hydrogen sulfide (H2S) is an important signaling molecule. This study examined the hypothesis that blood levels of H2S are lower in AA type 2 diabetic patients (T2D). Fasting blood was obtained from T2D and healthy controls. Results showed a significant decrease in plasma levels of cyclic adenosine monophosphate (cAMP) and H2S in AA T2D but not in Caucasian T2D when compared with those of respective age- and race-matched healthy controls. Plasma VD levels were significantly lower in AA T2D compared with Caucasian T2D. Cell culture studies demonstrate that 1,25(OH)2-VD supplementation significantly increased expression of cystathionine-γ-lyase (CSE), H2S formation, and cAMP secretion, but decreased reactive oxygen species in high glucose-treated U937 monocytes. This suggests that VD supplementation upregulates CSE and H2S formation and decreases oxidative stress, and that VD deficiency may contribute to the malfunctioning of H2S signaling and thus a higher incidence of vascular inflammation in AA. These results lead to the hypothesis that VD supplementation can replenish blood concentrations of H2S and cAMP and lower oxidative stress and cardiovascular disease in AA T2D. Antioxid. Redox Signal. 18, 1154–1158. |
| Databáze: | OpenAIRE |
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