Acute kidney injury in COVID-19: multicentre prospective analysis of registry data

Autor:	John R. Prowle, Yize I. Wan, Christopher J. Kirwan, Vanessa J Apea, Zudin Puthucheary, Rupert M Pearse, Chloe Orkin, Zuzanna Bien, Rageshri Dhairyawan
Rok vydání:	2021
Předmět:	medicine.medical_specialty medicine.medical_treatment 030232 urology & nephrology urologic and male genital diseases survival analysis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine Renal replacement therapy Risk factor AcademicSubjects/MED00340 Survival analysis Transplantation Creatinine business.industry Hazard ratio Acute kidney injury COVID-19 Odds ratio medicine.disease female genital diseases and pregnancy complications acute kidney injury chemistry Nephrology Original Article business Kidney disease
Zdroj:	Clinical Kidney Journal
ISSN:	2048-8505
Popis:	Background Acute kidney injury (AKI) is a common and important complication of COVID-19. Further characterisation is required to reduce both short and long-term adverse outcomes. Methods We examined registry data including adults with confirmed SARS-CoV-2 infection admitted to five London Hospitals from 1st January to 14th May 2020. Prior end-stage kidney disease was excluded. Early AKI was defined by Kidney Disease Improving Global Outcomes (KDIGO) creatinine criteria within 7 days of admission. Independent associations of AKI and survival were examined in multivariable analysis. Results are given as odds ratios (OR), or hazard ratios (HR) with 95% confidence intervals. Results Amongst 1855 admissions, 453 patients (24.5%) developed early AKI: 220 (44.0%) stage 1, 90 (19.8%) stage 2, 165 (36.3%) stage 3 (74 receiving renal replacement therapy). The strongest risk factor for AKI was high CRP (OR 3.35 [2.53-4.47], p Graphical Abstract Graphical Abstract
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8595860f4b4a039864bc611e8399d30f https://pubmed.ncbi.nlm.nih.gov/34751235 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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