Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy

Autor:	Sachiyo Tomita, Masahiro Egawa, Atsushi Saito, Daichi Kita, Miki Tanaka, Atsushi Yokomizo, Takashi Kinumatsu, Asako Makino-Oi
Rok vydání:	2018
Předmět:	Adult Male 0301 basic medicine Saliva Periodontal examination 030106 microbiology lcsh:Medicine Dentistry Pilot Projects General Biochemistry Genetics and Molecular Biology Crevicular fluid 03 medical and health sciences 0302 clinical medicine Periodontal disease medicine Dentifrice Humans In patient Periodontitis lcsh:Science (General) lcsh:QH301-705.5 Dentifrices Aged business.industry lcsh:R Supportive periodontal therapy Gingival Crevicular Fluid 030206 dentistry General Medicine Middle Aged medicine.disease Bactericidal ingredients Anti-Bacterial Agents Clinical trial Research Note Treatment Outcome lcsh:Biology (General) Female business lcsh:Q1-390
Zdroj:	BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018) BMC Research Notes
ISSN:	1756-0500
DOI:	10.1186/s13104-018-3216-x
Popis:	Objective This study aimed to evaluate clinically the effect of a novel dentifrice containing three kinds of bactericidal ingredients on periodontal disease. Results This was a single-arm, prospective clinical study that enrolled patients with periodontitis undergoing supportive periodontal therapy. Periodontal examination, microbiological testing of saliva samples, and evaluation of inflammatory markers (IL-1β, IL-6, IL-8, TNF-α) in gingival crevicular fluid were performed. After 4 weeks of the use of test dentifrice, these parameters were re-evaluated. The use of dentifrice was also subjectively evaluated by clinicians and participants. Among 30 participants, there were significant improvements in the periodontal and microbiological parameters, and the level of interleukin-1β in the gingival crevicular fluid, following the use of the test dentifrice. In clinicians’ subjective evaluation of the overall usefulness of the dentifrice, ‘mild’ and ‘moderate’ improvement accounted for 83% of the total responses. In the participants’ subjective evaluation, the majority indicated their experience of the use as favorable. Within the limitations of this study, it is suggested that the progression of periodontal disease during the supportive periodontal therapy can be prevented by the use of the test dentifrice. Trial registration UMIN Clinical Trials Registry (UMIN-CTR) 000023175. Date of formal registration: July 14, 2016 (https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000026716)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8595229d02c0af6e8c28d715034d8574 https://doi.org/10.1186/s13104-018-3216-x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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