| Autor: |
Meng-Meng, Liu, Feng-Feng, Zhang, Hui, Liu, Mei-Juan, Wu, Zhou-Jie, Liu, Pin-Fang, Huang |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Talanta. 254:124118 |
| ISSN: |
0039-9140 |
| DOI: |
10.1016/j.talanta.2022.124118 |
| Popis: |
Cell viability, as an important index to evaluate drug effects, usually was measured by tetrazolium colorimetric assay, playing a key role in drug development and drug screening. Tedious operating procedures, unsatisfactory sensitivity and abominable environments perplex researchers to acquire more detailed in vivo-relevant biological information. Herein, a simple and low-cost cell viability and drug evaluation biosensing system-based on multiwalled carbon nanotubes, gold nanoparticles and Nafion modified screen-printed electrode (SPE) biosensor was constructed for detection of dopamine (DA) released from living cells to evaluate cytotoxicity of antineoplastic drugs such as cisplatin and resveratrol. The biosensing system was demonstrated to display exceptional selectivity, excellent flexibility and good stability toward DA measurement in complex bio-samples. Additionally, the satisfactory recoveries of DA in real samples revealed the reliability and accuracy of the biosensing system in practical application. The IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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