Non-opiate analgesia following stressful acoustic stimulation
| Autor: | G. Benedek, J. Hideg, Margit Szikszay |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
medicine.drug_class Analgesic Pain Experimental and Cognitive Psychology Stimulation (+)-Naloxone Calcium channel blocker Substance P Sincalide Diltiazem Behavioral Neuroscience Stress Physiological medicine Animals Morphine Naloxone business.industry Rats Inbred Strains Rats Nociception Acoustic Stimulation Anesthesia Endorphins Analgesia Opiate business medicine.drug |
| Zdroj: | Physiology & Behavior. 35:135-138 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/0031-9384(85)90185-4 |
| Popis: | The change in the nociceptive reactions of rats was characterized after stressful acoustic (115 dB) stimulation. Acoustic loading for five minutes resulted in considerable analgesia in the hot-plate test, whereas a significant analgesic response was not observed in the tail-flick test. The analgesic reaction after acoustic stimulation was resistant to naloxone pretreatment and was also found in morphine-tolerant rats, but the acute thermoregulatory and analgesic effects of morphine were greatly potentiated by simultaneous acoustic loading. Substance P or cholecystokinin treatment likewise failed to prevent the analgesic effect of auditory stimulation. No tolerance developed to the analgesic effect on repeated stressing. Diltiazem, a slow calcium channel blocker, facilitated the analgesia. The data suggest a stress-induced analgesia with obviously non-opiate properties, although an indirect involvement of opiate effects could not be excluded. |
| Databáze: | OpenAIRE |
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