The chemical speciation of uranium in water does not influence its absorption from the gastrointestinal tract of rats
| Autor: | P. Houpert, François Paquet, Sandrine Frelon, Lepetit D |
|---|---|
| Přispěvatelé: | Laboratoire de radiotoxicologie et radiobiologie expérimentale (LRTOX), Institut de Radioprotection et de Sûreté Nucléaire (IRSN) |
| Rok vydání: | 2005 |
| Předmět: |
Male
stomach juice ex vivo study [SDV]Life Sciences [q-bio] 010501 environmental sciences Toxicology 01 natural sciences 030218 nuclear medicine & medical imaging Rats Sprague-Dawley 0302 clinical medicine water sampling Ingestion rat media_common Gastrointestinal tract Gastric Juice dosimetry Chemical speciation pH species differentiation article General Medicine water contamination Uranium fluid intake Environmental chemistry saliva level Absorption (pharmacology) gastrointestinal absorption media_common.quotation_subject animal experiment chemistry.chemical_element urine level animal tissue in vivo study 03 medical and health sciences In vivo chemical composition Animals controlled study human Saliva 0105 earth and related environmental sciences Ions nonhuman Radiochemistry Water feces level Rats Contaminated water Gastrointestinal Tract Speciation chemistry Intestinal Absorption validation process human versus nonhuman data computer model Sprague-Dawley |
| Zdroj: | Chemical Research in Toxicology Chemical Research in Toxicology, 2005, 18 (7), pp.1150-1154. ⟨10.1021/tx049662i⟩ |
| ISSN: | 0893-228X |
| DOI: | 10.1021/tx049662i⟩ |
| Popis: | Studies of the chemical speciation of uranium in water can enhance the knowledge of the mechanisms of its absorption from the gastrointestinal tract and its storage in the body. They can also help to improve the dosimetric models recommended by the International Commission on Radiological Protection (ICRP). The aim of this work was to assess the influence of uranium speciation on its absorption from the gastrointestinal tract by using both computer speciation modeling and direct measurement of the fractional absorption in vivo in rats after ingestion of five different samples of contaminated water. Preliminary ex vivo studies with human saliva and gastric juice showed that 90% of uranium was recovered with the natural components of the fluid studied. The computer studies of uranium speciation among the electrolytes of these fluids showed that under the set conditions, the chemical species changed in a broadly similar manner under the influence of fluid composition and pH. In vivo studies in rats validated these observations by indicating an average fractional absorption of about 0.4% for each of five different water samples. It is concluded that the chemical form of uranium in the water ingested did not influence its absorption into the body. © 2005 American Chemical Society. |
| Databáze: | OpenAIRE |
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