Synthesis of new water-soluble dihydropyridine vasodilators
| Autor: | Ryutaro Kawai, Toichi Takenaka, Tamazawa Kazuharu, Murakami Masuo, Fujimoto Masaharu, Kozo Takahashi, Iwanami Masaru, Tadao Shibanuma |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Nifedipine
Chemistry Hydrochloride Stereochemistry Pyridines Vasodilator Agents Dihydropyridine Water Vasodilation General Chemistry General Medicine Bioavailability chemistry.chemical_compound Nicardipine Structure-Activity Relationship Water soluble Solubility Drug Discovery Nicardipine Hydrochloride medicine Organic chemistry medicine.drug |
| Zdroj: | Chemicalpharmaceutical bulletin. 27(6) |
| ISSN: | 0009-2363 |
| Popis: | Several kinds of water-soluble dihydropyridine vasodilators were prepared and their vasodilating activities were evaluated. Among them, 2-(N-benzyl-N-methylamino)-ethyl methyl 2, 6-dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate hydrochloride (YC-93) was found to have outstanding activity and bioavailability. Various synthetic routes for this compound were examined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|