Synthesis and antibacterial activities of new 1β-methylcarbapenems having aminopyrimidinylthioether moiety
| Autor: | Yong Koo Kang, Kug-Seung Lee, Dong Chan Kim, Kye Jung Shin, J. H. Lim, Dukjoon Kim, Kyung Ho Yoo |
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| Rok vydání: | 2006 |
| Předmět: |
Pharmacology
Dipeptidases Magnetic Resonance Spectroscopy Molecular Structure Bicyclic molecule Chemistry Stereochemistry Organic Chemistry Microbial Sensitivity Tests General Medicine Sulfides Chemical synthesis Pyrrolidine Anti-Bacterial Agents chemistry.chemical_compound Pyrimidines Carbapenems Drug Discovery Moiety Antibacterial activity Membrane dipeptidase Antibacterial agent |
| Zdroj: | European Journal of Medicinal Chemistry. 41:1347-1351 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2006.08.003 |
| Popis: | The synthesis of new 1β-methylcarbapenems 1a – d bearing aminopyrimidinylthioether moiety at C-5 position of pyrrolidine ring and their antibacterial activities are described. All the compounds exhibited potent antibacterial activity. Of these carbapenems, 1d showed the best combination of antibacterial activity and stability to dehydropeptidase-I (DHP-I). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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