Ianthesine E, a new bromotyrosine-derived metabolite from the Great Barrier Reef sponge Pseudoceratina sp
| Autor: | John A. Kalaitzis, Ronald J. Quinn, John N. A. Hooper, Priscila de Almeida Leone |
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| Rok vydání: | 2008 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Magnetic Resonance Spectroscopy Metabolite CHO Cells Plant Science Biochemistry Analytical Chemistry HeLa chemistry.chemical_compound Cricetulus Cricetinae medicine Animals Humans Cytotoxicity Chromatography High Pressure Liquid biology Receptor Adenosine A1 Ligand binding assay Organic Chemistry biology.organism_classification Adenosine Adenosine receptor Porifera Sponge chemistry Cell culture Tyrosine Spectrophotometry Ultraviolet medicine.drug |
| Zdroj: | Natural Product Research. 22:1257-1263 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786410701763411 |
| Popis: | The new compound ianthesine E (1) was isolated from the Great Barrier Reef marine sponge Pseudoceratina sp. along with the known metabolites 11-hydroxyaerothionin (2), aerothionin (3) and 11,19-dideoxyfistularin 3 (4). Structures were determined on the basis of their spectroscopic data. The compounds were tested for inhibition of [(3)H] DPCPX binding to adenosine A(1) receptors in a whole cell binding assay. At 100 microM, aerothionin was the most potent, inhibiting 67% of binding, followed by ianthesine E and 11-hydroxyaerothionin which inhibited 61% of binding, and 11,19-dideoxyfistularin which initiated 51% of binding Ianthesine E (EC(50) 60 microM), aerothionin (EC(50) 42 microM) and 11,19-dideoxyfistularin-3 (EC(50) 2.6 microM) exhibited moderate cytotoxicity against the HeLa cell line. |
| Databáze: | OpenAIRE |
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