Biaryl Formation from 5-(2-Bromobenzyl)-Substituted Piperidin-2-ones via Palladacycles

Autor:	Gedu Satyanarayana, Martin E. Maier
Rok vydání:	2008
Předmět:	Allylic rearrangement Chemistry Aryl Organic Chemistry Substituent chemistry.chemical_element Metallacycle Biochemistry Medicinal chemistry chemistry.chemical_compound Bromide Physical and Theoretical Chemistry Palladium catalyst Palladium
Zdroj:	Organic Letters. 10:2361-2364
ISSN:	1523-7052 1523-7060
Popis:	The reaction of piperdin-2-ones with a 2-bromobenzyl substituent in the 5-position in the presence of a palladium catalyst leads to biaryl compounds. Their formation can be explained via initial C-H insertion of the aryl palladium species into the allylic C-H bond of the piperidinone. This eventually leads to a metallacycle containing Pd(II) that inserts another aryl bromide, promoting the formation of the biaryl bond.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859225043c23dfe236f85d600f03c1d3 https://doi.org/10.1021/ol800330d Zobrazit plný text záznamu