Biaryl Formation from 5-(2-Bromobenzyl)-Substituted Piperidin-2-ones via Palladacycles
Autor: | Gedu Satyanarayana, Martin E. Maier |
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Rok vydání: | 2008 |
Předmět: | |
Zdroj: | Organic Letters. 10:2361-2364 |
ISSN: | 1523-7052 1523-7060 |
Popis: | The reaction of piperdin-2-ones with a 2-bromobenzyl substituent in the 5-position in the presence of a palladium catalyst leads to biaryl compounds. Their formation can be explained via initial C-H insertion of the aryl palladium species into the allylic C-H bond of the piperidinone. This eventually leads to a metallacycle containing Pd(II) that inserts another aryl bromide, promoting the formation of the biaryl bond. |
Databáze: | OpenAIRE |
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