Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment

Autor: Miki Ojima, Nobuo Okahashi, N. Makiura, Atsuo Amano, Nobumichi Furuta, Y. Kou, Satoshi Shizukuishi
Rok vydání: 2008
Předmět:
Blood Glucose
Male
Gingival and periodontal pocket
Colony Count
Microbial
Dentistry
Aggregatibacter actinomycetemcomitans
Gastroenterology
chemistry.chemical_compound
Bacteroides
Aged
80 and over
biology
Prevotella intermedia
Treponema denticola
Middle Aged
C-Reactive Protein
Cholesterol
Female
medicine.symptom
Porphyromonas gingivalis
Adult
Microbiology (medical)
medicine.medical_specialty
Subgingival Curettage
Immunology
Bleeding on probing
Microbiology
Internal medicine
medicine
Humans
Periodontal Pocket
Periodontitis
General Dentistry
Triglycerides
Aged
Glycated Hemoglobin
business.industry
Cholesterol
HDL
Type 2 Diabetes Mellitus
Cholesterol
LDL
biology.organism_classification
medicine.disease
Diabetes Mellitus
Type 2
chemistry
Fimbriae
Bacterial
Glycated hemoglobin
Gingival Hemorrhage
business
Follow-Up Studies
Zdroj: Oral Microbiology and Immunology. 23:348-351
ISSN: 1399-302X
0902-0055
DOI: 10.1111/j.1399-302x.2007.00426.x
Popis: Introduction: The aim of this study was to assess the relationship between serum glycemic levels and subgingival microbial profile alteration following periodontal treatment in patients with type 2 diabetes mellitus. Methods: We studied 30 periodontitis patients with type 2 diabetes mellitus who received full-mouth subgingival debridement by analyzing their subgingival microbial profiles using a polymerase chain reaction method at baseline and various time-points for 12 months following treatment. Concurrently, probing pocket depth, bleeding on probing, and metabolic parameters, including glycated hemoglobin A1c (HbA1c), blood sugar level, C-reactive proteins, total cholesterol, triglyceride, and high-density and low-density lipoprotein cholesterol, were recorded. Results: Periodontal conditions were significantly improved after treatment, and the occurrence rates of periodontal bacterial species, including Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia, were also reduced. Interestingly, P. gingivalis was detected more frequently in subjects with increased HbA1c values after periodontal treatment than in those patients with decreased HbA1c values. Furthermore, P. gingivalis with type II fimbriae was detected only in HbA1c-increased subjects, while improvements in HbA1c values were observed only in subjects without type II clones. Conclusions: These results suggest that glycemic level in diabetes is affected by the persistence of P. gingivalis, especially clones with type II fimbriae, in periodontal pockets.
Databáze: OpenAIRE
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