Dietary Intake of Melatonin from Tropical Fruit Altered Urinary Excretion of 6-Sulfatoxymelatonin in Healthy Volunteers
| Autor: | Nutjaree Pratheepawanit Johns, Manit Sae-Teaw, Jeffrey Johns, Supatra Porasuphatana, Preeyaporn Plaimee |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male 6-sulfatoxymelatonin medicine.medical_specialty Antioxidant Adolescent medicine.medical_treatment Health Promotion Urine Orange (colour) Ananas Biology Melatonin Excretion Young Adult Internal medicine Healthy volunteers medicine Humans Tropical Climate Cross-Over Studies food and beverages Musa General Chemistry Crossover study Diet Endocrinology Fruit Female General Agricultural and Biological Sciences hormones hormone substitutes and hormone antagonists Citrus sinensis medicine.drug |
| Zdroj: | Journal of Agricultural and Food Chemistry. 61:913-919 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf300359a |
| Popis: | This study assessed the melatonin content of six tropical fruits and examined whether human consumption could contribute to dietary melatonin as measured by 6-sulfatoxymelatonin (aMT6-s, a marker of circulating melatonin in the body). Melatonin was extracted using methanol and analyzed by high-performance liquid chromatography. In a clinical crossover study, 30 healthy volunteers consumed selected fruits one at a time, with a 1week wash-out period between fruits, until completing all six fruits. Most fruits had moderate melatonin content. Significant increases in urine aMT6-s concentrations were seen after the consumption of pineapple (266%, p = 0.004), banana (180%, p = 0.001), and orange (47%, p = 0.007). The need to analyze melatonin both in fruit and as in vivo uptake was demonstrated. Further study is warranted regarding the clinical effect of fruit consumption in people with age-related melatonin reduction problems such as sleeplessness and illnesses involving oxidative damage. |
| Databáze: | OpenAIRE |
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