HPP and SGQR peptides from silkworm pupae protein hydrolysates regulated biosynthesis of cholesterol in HepG2 cell line
| Autor: | Wang Junhong, Faizan A. Sadiq, Nan Wang, Sun Suling, Zhang Yu, Zhu Zuoyi, Xue Li, Qianhui Qi, Qihe Chen, Guohua Zhang, Yang Hua, Wang Wei |
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| Rok vydání: | 2021 |
| Předmět: |
Nutrition and Dietetics
Neutral proteinase Ser-Gly-Gln-Arg Nutrition. Foods and food supply Cholesterol Medicine (miscellaneous) Glutaryl-coenzyme A Reductase His-Pro-Pro 3-Hydroxy-3-methyl glutaryl coenzyme A reductase chemistry.chemical_compound Biosynthesis chemistry Biochemistry Hepg2 cells Molecular docking Silkworm pupae TX341-641 lipids (amino acids peptides and proteins) Protein hydrolysates Food Science |
| Zdroj: | Journal of Functional Foods, Vol 77, Iss, Pp 104328-(2021) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2020.104328 |
| Popis: | To screen several peptides that could possibly inhibit the biosynthesis of cholesterol, we selected peptides with high 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGCR) inhibitory activity from silkworm pupae protein hydrolysates (SPPHs). SPPH was obtained by hydrolysing the proteins with neutral proteinase, and filtered to 5 kDa fractions. Fraction 4 (SPP) with the highest HMGCR inhibitory activity was acquired from the ultrafiltrate ( |
| Databáze: | OpenAIRE |
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