Gastrin-releasing peptide: neuronal distribution and spatial relation to endocrine cells in the human upper gut
| Autor: | L. Lundell, Frank Sundler, Eva Ekblad, M. Sjövall |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Clinical Biochemistry Enteroendocrine cell Biology digestive system Biochemistry Cellular and Molecular Neuroscience Endocrinology Internal medicine Gastrin-releasing peptide Pyloric Antrum medicine Humans Aged Gastrin Neurons Stomach digestive oral and skin physiology Middle Aged Immunohistochemistry medicine.anatomical_structure Somatostatin Gastrin-Releasing Peptide Gastric Mucosa Duodenum Female Neuron G cell Peptides hormones hormone substitutes and hormone antagonists |
| Zdroj: | Regulatory Peptides. 28:47-55 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/0167-0115(90)90063-3 |
| Popis: | By using immunocytochemical techniques, we have studied the distribution of gastrin releasing peptide (GRP)-containing neurons as well as the spatial relationship between these neurons and the endocrine cells in the human stomach and duodenum. Moderate numbers of immunoreactive fibers were distributed in the smooth muscle and submucosa of the stomach; they were more rare in the duodenal wall. Numerous GRP-containing nerve fibers were found in the oxyntic mucosa, the antral mucosa harboured only few GRP immunoreactive nerve fibers. The mucosa of the proximal duodenum was found to be virtually devoid of such fibers. Only occasionally did we observe signs of a direct contact between GRP-containing nerve fibers and gastrin and somatostatin cells in the antral mucosa. In the oxyntic mucosa GRP-containing nerve fibers sometimes seemed to contact endocrine cells, including somatostatin cells as well as individual parietal cells. In conclusion, although GRP-containing nerve fibers were quite numerous in the wall of the human upper gastro-intestinal (GI)-tract, we observed a lack of intimate spatial relationship between these fibers and endocrine cells in the antral mucosa, suggesting additive mechanisms to a direct innervation of gastrin cells and somatostatin cells by GRP nerve fibers explaining the physiological effects on hormonal release. |
| Databáze: | OpenAIRE |
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