Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice
| Autor: | Roberto Farina de Almeida, Diogo O. Souza, Tadeu Mello e Souza, Flávia L. Ribeiro-Gomes, Guilherme Loureiro Werneck, Luciana Pereira de Sousa, Cláudio Tadeu Daniel-Ribeiro |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Plasmodium berghei Science Immunology chemical and pharmacologic phenomena Diseases Anxiety Affect (psychology) Article 03 medical and health sciences 0302 clinical medicine Immune system Memory parasitic diseases medicine Animals Cognitive Dysfunction Recognition memory Multidisciplinary biology business.industry Cognition Recognition Psychology biology.organism_classification medicine.disease Malaria Mice Inbred C57BL 030104 developmental biology Ageing Immune System Medicine Female Immunization business Neuroscience Neurocognitive 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| ISSN: | 2045-2322 |
| Popis: | The immune system plays a role in the maintenance of healthy neurocognitive function. Different patterns of immune response triggered by distinct stimuli may affect nervous functions through regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here, we investigate the effect of immune stimulation on cognitive-behavioural parameters in healthy mice and its impact on cognitive sequelae resulting from non-severe experimental malaria. We show that immune modulation induced by a specific combination of immune stimuli that induce a type 2 immune response can enhance long-term recognition memory in healthy adult mice subjected to novel object recognition task (NORT) and reverse a lack of recognition ability in NORT and anxiety-like behaviour in a light/dark task that result from a single episode of mild Plasmodium berghei ANKA malaria. Our findings suggest a potential use of immunogens for boosting and recovering recognition memory that may be impaired by chronic and infectious diseases and by the effects of ageing. |
| Databáze: | OpenAIRE |
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