E2F1 Expression Predicts Outcome in Korean Women Who Undergo Surgery for Breast Carcinoma

Autor: Eun Sook Nam, Won Jae Lee, Hye Rim Park, Mi Jung Kwon, Chan Heun Park, Hyung Sik Shin, Jun Ho Park, Seong Jin Cho
Rok vydání: 2009
Předmět:
Adult
Oncology
endocrine system
medicine.medical_specialty
Neoplasms
Hormone-Dependent
medicine.medical_treatment
Breast Neoplasms
Immunoenzyme Techniques
Breast cancer
E2F2 Transcription Factor
Surgical oncology
Internal medicine
medicine
Humans
Neoplasm Invasiveness
Stage (cooking)
Survival rate
Lymph node
Mastectomy
Aged
Neoplasm Staging
Aged
80 and over
Korea
business.industry
Carcinoma
Ductal
Breast
Middle Aged
medicine.disease
Combined Modality Therapy
Survival Rate
Carcinoma
Lobular
Treatment Outcome
medicine.anatomical_structure
Receptors
Estrogen
Chemotherapy
Adjuvant
Tissue Array Analysis
Lymphatic Metastasis
Invasive lobular carcinoma
Female
Surgery
Neoplasm Recurrence
Local
biological phenomena
cell phenomena
and immunity
Receptors
Progesterone
Breast carcinoma
business
E2F1 Transcription Factor
Zdroj: Annals of Surgical Oncology. 17:564-571
ISSN: 1534-4681
1068-9265
DOI: 10.1245/s10434-009-0767-z
Popis: The transcriptional factors E2F1 and E2F2 have been reported to be associated with improved chemosensitivity in various cancers. We aimed to investigate whether E2F1 and E2F2 can be used as predictors of chemosensitivity in hormone-receptor-negative breast cancers (HRNBCs), which are common in Korean women. A total of 183 patients with primary breast cancer who had undergone surgical resection were evaluated on the basis of hormonal status, age, histological subtype and grade, tumor size, lymph node metastasis, and stage. The immunohistochemical expressions of E2F1 and E2F2 were analyzed for these histopathological data and patient survival. E2F1 expression was associated with low histological grade (grade 1) and larger tumor size (>2 cm), while E2F2 expression was correlated only with large tumor size (>2 cm). The E2F1-positive group had less tumor recurrences, lymph node metastases during follow-up, and distant metastases than the E2F1-negative group; E2F1 expression was found to be an independent predictive factor of more favorable survival among HRNBC patients on univariate and multivariate analyses, but E2F2 expression was not. E2F1 may be a potential prognostic and predictive factor for clinical outcome and therapeutic results following adjuvant chemotherapy in HRNBC patients.
Databáze: OpenAIRE
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