Response to peginterferon-alpha 2b and ribavirin in Japanese patients with chronic hepatitis C genotype 1

Autor: Ryosaku Azemoto, Noriaki Suzuki, Yasuo Hirai, Motohide Takashi, Tatsuo Miyamura, Michio Kimura, Akinobu Tawada, Osamu Yokosuka, Shuang Wu, Tomoo Miyauchi, Keiichi Fujiwara, Nobuyuki Sugiura, Rintaro Mikata, Shigeru Mikami, Shingo Nakamoto, Makoto Arai, Takeshi Tanaka, Yutaka Natsuki, Tatsuo Kanda, Fumio Imazeki
Rok vydání: 2011
Předmět:
Zdroj: Hepatology international. 7(1)
ISSN: 1936-0533
Popis: Patient age and gender may be associated with response to peginterferon alpha plus ribavirin, the current standard of care (SOC) for chronic hepatitis C genotype 1. We queried whether there was an association between age, gender, and treatment response to SOC in Japanese patients infected with hepatitis C virus (HCV) genotype 1. Between 2006 and 2009, HCV-infected Japanese patients treated with peginterferon alpha-2b plus ribavirin for 48 weeks were enrolled. Patients were allocated into four groups according to age and gender, and epidemiological data and treatment outcomes were retrospectively analyzed. HCV RNA was measured with COBAS AMPLICOR HCV Monitor Test v. 2.0. The overall sustained virological response (SVR) rate was 49.8%: patients aged ≤65 and >65 years, 50.9 and 44.0%, respectively; male and female, 56.5 and 39.0%. SVR rates of SOC against HCV genotype-1 females aged >65 years (19.0%) were inferior to those in males aged >65 years (57.8%) in Japan. Multivariate logistic regression analysis showed that SVR was attained independently of adherence 80/80/80 in all groups. Adherence to medication is also a key factor for the eradication of HCV in patients aged >65 years. As the SVR rate of patients aged ≤65 years was similar to that of patients aged >65 years, SOC could be useful for treating some of the elderly patients.
Databáze: OpenAIRE
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